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How to get fromNaples to Florenceby bus (Flixbus), bus, train, car, or plane

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There are 6 ways to get from Naples to Florence by bus (Flixbus), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Naples, FL to University of South Florida - 3801 USF Holly Drbus bus
    2. Take the bus from University of South Florida to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Florencebus bus
    15h 39m
    $161–272

  2. Fly Ft. Myers to Florence Regional Airport

    cheapest
    1. Fly from Ft. Myers (RSW) to Florence Regional Airport (FLO)plane plane RSW - FLO
    9h 58m
    $104–481

  3. Bus, train

    1. Take the bus from Naples, FL to Fort Myers 7-11bus bus
    2. Take the bus from Fort Myers Amtrak Bus Stop to Orlandobus bus
    3. Take the train from Orlando to Florence Stationtrain train
    18h 33m
    $252–486

  4. Drive 631.8 mi

    1. Drive from Naples to Florencecar car 631.8 mi
    11h 4m
    $116–167

  5. Bus to Miami International Airport, fly to Charleston International Airport, train

    1. Take the bus from Naples, FL to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    9h 51m
    $584–1,151

  6. Line 11 bus, line 600 bus, line 240 bus to Ft. Myers, fly to Charleston International Airport, line 104 bus, train

    1. Take the bus from 3rd Ave S to Creekside WLinCbus bus
    2. Take the bus from Creekside Way Transfer @ Immokalee Rd to Coconut Point Mallbus bus
    3. Take the bus from Coconut Point Mall to South Fort Myers Transfer/P&Rbus bus
    4. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    5. Take the bus from N. Charleston SuperStop to North Charleston Transit Centerbus bus
    6. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    12h 7m

Ft. Myers (RSW) to Florence Regional Airport (FLO) flights

Calendar26Weekly Planes
Duration6h 6mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

Map of how to get from Naples to Florence.ExpandLaunch map view
  • Distance: 723.9 mi
  • Duration: 15h 39m

What companies run services between Naples, FL, USA and Florence, SC, USA?

You can take a vehicle from Naples to Florence via Naples, FL, University of South Florida, Orlando Bus Station, and Florence in around 15h 39m. Alternatively, American Airlines flies from Ft. Myers (RSW) to Florence Regional Airport (FLO) 4 times a day.

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