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How to get fromNaples to Knoxvilleby bus, plane, train, bus (Flixbus), or car

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There are 7 ways to get from Naples to Knoxville by bus, plane, train, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Miami International Airport, fly

    best
    1. Take the bus from Naples, FL to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Mcghee Tyson Airport (TYS)plane plane MIA - TYS
    5h 43m
    $225–802

  2. Drive 786.6 mi

    cheapest
    1. Drive from Naples to Knoxvillecar car 786.6 mi
    13h 56m
    $144–208

  3. Bus, train via Orlando

    1. Take the bus from Naples, FL to Fort Myers 7-11bus bus
    2. Take the bus from Fort Myers Amtrak Bus Stop to Orlandobus bus
    3. Take the train from Orlando to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    44h 34m
    $635–1,159

  4. Bus

    1. Take the bus from Naples, FL to University of South Florida - 3801 USF Holly Drbus bus
    2. Take the bus from University of South Florida to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    45h 33m
    $355–549

  5. Bus, bus to Fort Lauderdale–Hollywood International Airport, fly

    1. Take the bus from Naples, FL to Miami Airportbus bus
    2. Take the bus from Miami Airport to Fort Lauderdale Airportbus bus
    3. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    7h 8m
    $241–865

  6. Fly from Ft. Myers

    1. Fly from Ft. Myers (RSW) to Mcghee Tyson Airport (TYS)plane plane RSW - TYS
    10h 3m
    $210–878

  7. Bus, train

    1. Take the bus from Naples, FL to Miami Airportbus bus
    2. Take the train from Hollywood Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    45h 25m
    $621–1,151

Miami International Airport (MIA) to Mcghee Tyson Airport (TYS) flights

Calendar43Weekly Planes
Duration4h 2mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

Map of how to get from Naples to Knoxville.ExpandLaunch map view
  • Distance: 854.7 mi
  • Duration: 5h 43m

What companies run services between Naples, FL, USA and Knoxville, TN, USA?

You can take a vehicle from Naples to Knoxville Station Hall of Fame via Naples, FL, University of South Florida, Orlando Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 45h 33m. Alternatively, Delta, American Airlines, and two other airlines fly from Ft. Myers (RSW) to Mcghee Tyson Airport (TYS) hourly.

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