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How to get fromNaples to Santeeby bus, plane, car, train, bus (Flixbus), or taxi

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There are 9 ways to get from Naples to Santee by bus, plane, car, train, bus (Flixbus), or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Miami International Airport, fly to Charleston International Airport, drive

    best
    1. Take the bus from Naples, FL to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 9m
    $560–1,098

  2. Drive 565.3 mi

    cheapest
    1. Drive from Naples to Santeecar car 565.3 mi
    9h 58m
    $104–149

  3. Bus, train, drive

    1. Take the bus from Naples, FL to Miami Airportbus bus
    2. Take the train from Hollywood Amtrak Station to Charleston Amtrak Stationtrain train
    3. Drive from Charleston Amtrak Station to Santeecar car
    18h 24m
    $263–534

  4. Bus (Flixbus)

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus FlixBus 2421
    2. Take the bus from Orlando Bus Station to Orangeburgbus bus FlixBus 2433
    19h 12m
    $178–279

  5. Bus, bus to Fort Lauderdale–Hollywood International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Naples, FL to Miami Airportbus bus
    2. Take the bus from Miami Airport to Fort Lauderdale Airportbus bus
    3. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    4. Drive from Charleston-Airport-CHS to Santeecar car
    7h 32m
    $236–1,211

  6. Line 11 bus, line 600 bus, line 240 bus to Ft. Myers, fly to Charleston International Airport, drive

    1. Take the bus from 3rd Ave S to Creekside WLinCbus bus
    2. Take the bus from Creekside Way Transfer @ Immokalee Rd to Coconut Point Mallbus bus
    3. Take the bus from Coconut Point Mall to South Fort Myers Transfer/P&Rbus bus
    4. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    5. Drive from Charleston-Airport-CHS to Santeecar car
    8h 25m

  7. Fly Ft. Myers to Columbia, drive

    1. Fly from Ft. Myers (RSW) to Columbia (CAE)plane plane RSW - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    10h 29m
    $234–1,224

  8. Bus to Tampa, fly to Charleston International Airport, drive

    1. Take the bus from Naples, FL to University of South Florida - 3801 USF Holly Drbus bus
    2. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    9h 18m
    $216–474

  9. Bus, taxi

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Walterboro, SCbus bus
    4. Take the taxi from Walterboro, SC to Santeetaxi taxi
    19h 35m
    $190–291

Miami International Airport (MIA) to Charleston International Airport (CHS) flights

Calendar28Weekly Planes
Duration3h 47mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Naples to Santee.ExpandLaunch map view
  • Distance: 665.5 mi
  • Duration: 6h 9m

What companies run services between Naples, FL, USA and Santee, SC, USA?

You can take a bus from 3rd Ave S to Santee via Creekside WLinC, Creekside Way Transfer @ Immokalee Rd, Coconut Point Mall, South Fort Myers Transfer/P&R, Fort Myers Bus Stop, Orlando Bus Station, and Orangeburg in around 19h 12m.

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