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How to get fromNaples to Knoxvilleby plane, car, or train

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There are 6 ways to get from Naples to Knoxville by plane, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Naples Airport to Mcghee Tyson Airport

    best
    1. Fly from Naples Airport (NAP) to Mcghee Tyson Airport (TYS)plane plane NAP - TYS
    14h 30m
    $661–2,131

  2. Fly Naples Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Naples Airport (NAP) to Asheville Regional Airport (AVL)plane plane NAP - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    15h 33m
    $351–1,155

  3. Fly Naples Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Naples Airport (NAP) to Chattanooga Metropolitan Airport (CHA)plane plane NAP - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    15h 39m
    $669–2,235

  4. Fly Naples Airport to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Naples Airport (NAP) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane NAP - ATL
    2. Drive from Atlanta-Airport-ATL to Knoxvillecar car
    15h 12m
    $482–1,167

  5. Fly Naples Airport to Greenville–Spartanburg International Airport, drive

    1. Fly from Naples Airport (NAP) to Greenville–Spartanburg International Airport (GSP)plane plane NAP - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Knoxvillecar car
    17h 2m
    $525–1,736

  6. Train to Fiumicino International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Napoli Centrale to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Mcghee Tyson Airport (TYS)plane plane FCO - TYS
    16h 45m
    $637–2,053

Naples Airport (NAP) to Mcghee Tyson Airport (TYS) flights

Calendar38Weekly Planes
Duration18h 5mAverage Duration
Ticket$605Cheapest Price
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Questions & Answers

Map of how to get from Naples to Knoxville.ExpandLaunch map view
  • Distance: 5,047.2 mi
  • Duration: 14h 30m

What companies run services between Naples, Italy and Knoxville, TN, USA?

American Airlines, Delta, and three other airlines fly from Naples Airport (NAP) to Mcghee Tyson Airport (TYS) 5 times a day.

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