There are 9 ways to get from Natchez to Knoxville by car, plane, train, bus, taxi, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Baton Rouge Metropolitan Airport, fly
best- Drive from Natchez to Baton-Rouge-Airport-BTRcar
- Fly from Baton Rouge Metropolitan Airport (BTR) to Mcghee Tyson Airport (TYS)plane BTR - TYS
5h 32m$210–892Drive 591.6 mi
cheapest- Drive from Natchez to Knoxvillecar 591.6 mi
10h 19m$108–156Drive, train, bus, taxi, shuttle via Atlanta
- Drive from Natchez to Brookhaven Stationcar
- Take the train from Brookhaven Station to Jacksontrain
- Take the bus from Jackson to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus
- Take the bus from Charlotte to Boonebus
- Take the taxi from Boone to Black Bear Resorttaxi
- Take a shuttle bus from Black Bear Resort to Hot Springs
- Drive from Hot Springs to Chilhowee at Holstoncar
26h 28m$408–543Drive, train, bus, taxi, shuttle
- Drive from Natchez to Brookhaven Stationcar
- Take the train from Brookhaven Station to New Orleans Union Passenger Terminaltrain
- Take the train from New Orleans Union Passenger Terminal to High Pointtrain
- Take the bus from Forsyth Hospital to Boonebus
- Take the taxi from Boone to Black Bear Resorttaxi
- Take a shuttle bus from Black Bear Resort to Hot Springs
- Drive from Hot Springs to Knoxvillecar
35h 29m$547–920Taxi to Alexandria International Airport, fly
- Take the taxi from Natchez to Alexandria International Airport (AEX)taxi
- Fly from Alexandria International Airport (AEX) to Mcghee Tyson Airport (TYS)plane AEX - TYS
5h 54m$227–946Fly from Natchez
- Fly from Natchez (HEZ) to Mcghee Tyson Airport (TYS)plane HEZ - TYS
6h 56m$283–1,103Taxi to Monroe Regional Airport, fly
- Take the taxi from Natchez to Monroe Regional Airport (MLU)taxi
- Fly from Monroe Regional Airport (MLU) to Mcghee Tyson Airport (TYS)plane MLU - TYS
6h 8m$217–896Drive, train to Jackson/Vicksburg, fly
- Drive from Natchez to Brookhaven Stationcar
- Take the train from Brookhaven Station to Jacksontrain
- Fly from Jackson/Vicksburg (JAN) to Mcghee Tyson Airport (TYS)plane JAN - TYS
7h 53m$236–922Taxi to Lafayette Regional Airport, fly
- Take the taxi from Natchez to Lafayette Regional Airport (LFT)taxi
- Fly from Lafayette Regional Airport (LFT) to Mcghee Tyson Airport (TYS)plane LFT - TYS
7h 25m$227–946
Baton Rouge Metropolitan Airport (BTR) to Mcghee Tyson Airport (TYS) flights
Questions & Answers
The cheapest way to get from Natchez to Knoxville is to drive which costs $100 - $160 and takes 10h 19m.
The fastest way to get from Natchez to Knoxville is to drive and fly which takes 5h 32m and costs $210 - $900.
The distance between Natchez and Knoxville is 653 miles. The road distance is 595 miles.
It takes approximately 5h 32m to get from Natchez to Knoxville, including transfers.
Knoxville is 1h ahead of Natchez. It is currently 12:37 PM in Natchez and 1:37 PM in Knoxville.
Yes, the driving distance between Natchez to Knoxville is 595 miles. It takes approximately 10h 19m to drive from Natchez to Knoxville.
There are 324+ hotels available in Knoxville.
What companies run services between Natchez, MS, USA and Knoxville, TN, USA?
United Airlines and Allegiant Air fly from Natchez (HEZ) to Mcghee Tyson Airport (TYS) once daily.
- Website
- delta.com
Flights from Baton Rouge Metropolitan Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 18m
- When
- Friday, Sunday, Monday, Tuesday, Wednesday, and Thursday
- Estimated price
- $140–800
Flights from Alexandria International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 3h 53m
- When
- Every day
- Estimated price
- $150–850
Flights from Monroe Regional Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $140–800
Flights from Jackson/Vicksburg to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $120–750
Flights from Lafayette Regional Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $150–850
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Brookhaven Station to Jackson
- Ave. Duration
- 1h 14m
- Frequency
- Once daily
- Estimated price
- $14–35
- Website
- Amtrak
Train from Brookhaven Station to New Orleans Union Passenger Terminal
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $30–75
- Website
- Amtrak
Train from New Orleans Union Passenger Terminal to High Point
- Ave. Duration
- 20h 51m
- Frequency
- Once daily
- Estimated price
- $220–500
- Website
- Amtrak
Train from Brookhaven Station to Jackson
- Ave. Duration
- 1h 14m
- Frequency
- Once daily
- Estimated price
- $14–35
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Jackson to Atlanta Bus Station
- Ave. Duration
- 8h 10m
- Frequency
- Twice daily
- Estimated price
- $60–100
- Website
- Greyhound
Bus from Atlanta Bus Station to Charlotte Bus Station
- Ave. Duration
- 4h 10m
- Frequency
- Every 4 hours
- Estimated price
- $35–60
- Website
- Greyhound
- Ave. Duration
- 1h 54m
- Estimated price
- $22–150
High Country Taxi
- Phone
- +1 828-414-1492
- Website
- highcountrytaxi.com
Tipsy Taxi
- Phone
- +1 828-719-8477
- Website
- facebook.com
High Country Taxi
- Phone
- +1 828-414-1492
- Website
- highcountrytaxi.com
Tipsy Taxi
- Phone
- +1 828-719-8477
- Website
- facebook.com
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