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How to get fromNatchez to Louisvilleby plane, car, train, bus, or taxi

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There are 9 ways to get from Natchez to Louisville by plane, car, train, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Natchez

    best
    1. Fly from Natchez (HEZ) to Louisville International Airport (SDF)plane plane HEZ - SDF
    6h 36m
    $189–836

  2. Drive  656.1 mi

    cheapest
    1. Drive from Natchez to Louisvillecar car 656.1 mi
    12h 32m
    $120–173

  3. Drive, train, bus via Memphis

    1. Drive from Natchez to Brookhaven Stationcar car
    2. Take the train from Brookhaven Station to Jacksontrain train
    3. Take the bus from Jackson to Memphis Bus Stationbus bus
    4. Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus bus
    16h 8m
    $192–275

  4. Drive, train, bus

    1. Drive from Natchez to Brookhaven Stationcar car
    2. Take the train from Brookhaven Station to Champaign-Urbanatrain train
    3. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    21h 21m
    $423–697

  5. Drive to Baton Rouge Metropolitan Airport, fly

    1. Drive from Natchez to Baton-Rouge-Airport-BTRcar car
    2. Fly from Baton Rouge Metropolitan Airport (BTR) to Louisville International Airport (SDF)plane plane BTR - SDF
    6h 52m
    $146–725

  6. Taxi to Alexandria International Airport, fly

    1. Take the taxi from Natchez to Alexandria International Airport (AEX)taxi taxi
    2. Fly from Alexandria International Airport (AEX) to Louisville International Airport (SDF)plane plane AEX - SDF
    6h 56m
    $153–779

  7. Taxi to Monroe Regional Airport, fly

    1. Take the taxi from Natchez to Monroe Regional Airport (MLU)taxi taxi
    2. Fly from Monroe Regional Airport (MLU) to Louisville International Airport (SDF)plane plane MLU - SDF
    8h 23m
    $153–729

  8. Drive, train to Jackson/Vicksburg, fly

    1. Drive from Natchez to Brookhaven Stationcar car
    2. Take the train from Brookhaven Station to Jacksontrain train
    3. Fly from Jackson/Vicksburg (JAN) to Louisville International Airport (SDF)plane plane JAN - SDF
    8h 42m
    $177–720

  9. Drive, train, bus via Nashville

    1. Drive from Natchez to Brookhaven Stationcar car
    2. Take the train from Brookhaven Station to Jacksontrain train
    3. Take the bus from Jackson to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Nashville Bus Stationbus bus
    5. Take the bus from Nashville to Louisville, KYbus bus
    16h 20m
    $131–227

Natchez (HEZ) to Louisville International Airport (SDF) flights

Calendar12Weekly Planes
Duration6h 15mAverage Duration
Ticket$161Cheapest Price
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Comparing Your Travel Options

Map of how to get from Natchez to Louisville.ExpandLaunch map view
  • Distance: 568.5 mi
  • Duration: 6h 36m

What companies run services between Natchez, MS, USA and Louisville, KY, USA?

United Airlines flies from Natchez (HEZ) to Louisville International Airport (SDF) twice daily.

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