There are 6 ways to get from Natick to Buffalo by train, plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, fly to Buffalo Niagara International Airport
best- Take the train from Natick Center to Back Baytrain
- Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane BOS - BUF
5h 7m$93–521Bus (Greyhound)
cheapest- Take the bus from Boston to Buffalobus Greyhound US0171
13h 12m$70–138Train (Amtrak)
- Take the train from Framingham Amtrak to Buffalo Depew Stationtrain Lake Shore Limited
13h 34m$123–426Drive 438.9 mi
- Drive from Natick to Buffalocar 438.9 mi
7h 40m$81–116Fly to Rochester, bus
- Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane BOS - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
6h 31m$135–660Bus via Ithaca
- Take the bus from Boston to Ithacabus FlixBus 2691
- Take the bus from Ithaca to Buffalobus Adt N806
14h 20m$76–134
Natick to Buffalo by bus (Greyhound)
Questions & Answers
The cheapest way to get from Natick to Buffalo is to bus which costs $65 - $140 and takes 13h 12m.
The fastest way to get from Natick to Buffalo is to train and fly which takes 5h 7m and costs $90 - $550.
No, there is no direct bus from Natick to Buffalo. However, there are services departing from Natick Center MBTA and arriving at Buffalo via Framingham and Boston. The journey, including transfers, takes approximately 13h 12m.
No, there is no direct train from Natick to Buffalo. However, there are services departing from Natick Center and arriving at Buffalo via Framingham Amtrak and Buffalo Depew Station. The journey, including transfers, takes approximately 13h 34m.
The distance between Natick and Buffalo is 428 miles. The road distance is 441.5 miles.
The best way to get from Natick to Buffalo without a car is to bus which takes 13h 12m and costs $65 - $140.
It takes approximately 5h 7m to get from Natick to Buffalo, including transfers.
Natick to Buffalo bus services, operated by Greyhound USA, depart from Boston station.
Natick to Buffalo train services, operated by Amtrak, depart from Framingham Amtrak station.
The best way to get from Natick to Buffalo is to bus which takes 13h 12m and costs $65 - $140. Alternatively, you can train, which costs $120 - $430 and takes 13h 34m.
What companies run services between Natick, MA, USA and Buffalo, NY, USA?
Greyhound USA operates a bus from Boston to Buffalo once daily. Tickets cost $65–130 and the journey takes 10h 5m. Alternatively, Amtrak operates a train from Framingham Amtrak to Buffalo Depew Station once daily. Tickets cost $120–280 and the journey takes 11h 4m.
- Website
- aa.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $80–500
Flights from Boston Logan Airport to Rochester
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $95–600
Train from Natick Center to Back Bay
- Ave. Duration
- 40 min
- Frequency
- Hourly
- Estimated price
- $3–9
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $3–9
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Boston to Buffalo
- Ave. Duration
- 10h 5m
- Frequency
- Once daily
- Estimated price
- $65–130
- Website
- Greyhound
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 20m
- Frequency
- 5 times a day
- Estimated price
- $10–20
- Website
- Greyhound
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More Questions & Answers
Natick to Buffalo bus services, operated by Greyhound USA, arrive at Buffalo station.
Natick to Buffalo train services, operated by Amtrak, arrive at Buffalo Depew Station.
Yes, the driving distance between Natick to Buffalo is 441 miles. It takes approximately 7h 40m to drive from Natick to Buffalo.
There are 264+ hotels available in Buffalo.







