There are 6 ways to get from Natick to Eastham by train, bus, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, bus via Boston, South Station
best- Take the train from Natick Center to South Stationtrain
- Take the bus from Boston South Buses to Hyannis Transportation Centerbus
- Take the bus from Hyannis Transportation Center to Easthambus
4h 58m$35–57Train
cheapest- Take the train from South Station to Hyannistrain CapeFLYER
6h 1m$13–43Drive 101.4 mi
- Drive from Natick to Easthamcar 101.4 mi
2h 9m$19–27Train, bus
- Take the train from Natick Center to South Stationtrain
- Take the bus from Boston South Station to Hyannis Transportation Centerbus
- Take the bus from Hyannis Transportation Center to Easthambus
5h 1m$23–62Train, bus via Boston
- Take the train from Natick Center to South Stationtrain
- Take the bus from Boston to Hyannisbus
- Take the bus from Hyannis Transportation Center to Easthambus
5h 6m$23–62Bus
- Take the bus from Framingham to Bostonbus Greyhound US0270s
- Take the bus from Boston South Buses to Hyannis Transportation Centerbus Hyannis - South Shore to Logan Airport
6h 10m$36–60
Natick to Eastham by train and bus
Questions & Answers
The cheapest way to get from Natick to Eastham is to drive which costs $18 - $27 and takes 2h 9m.
The fastest way to get from Natick to Eastham is to drive which takes 2h 9m and costs $18 - $27.
No, there is no direct bus from Natick to Eastham. However, there are services departing from Framingham and arriving at Eastham via Boston South Buses and Hyannis Transportation Center. The journey, including transfers, takes approximately 6h 10m.
No, there is no direct train from Natick to Eastham. However, there are services departing from Natick Center and arriving at Hyannis via South Station. The journey, including transfers, takes approximately 6h 1m.
The distance between Natick and Eastham is 116 miles. The road distance is 102 miles.
The best way to get from Natick to Eastham without a car is to train and bus via Boston, South Station which takes 4h 58m and costs $35 - $60.
It takes approximately 4h 58m to get from Natick to Eastham, including transfers.
Natick to Eastham bus services, operated by Greyhound USA, depart from Framingham station.
Natick to Eastham train services, operated by Cape Flyer, depart from South Station.
The best way to get from Natick to Eastham is to train which takes 6h 1m and costs $13 - $45. Alternatively, you can bus, which costs $35 - $60 and takes 6h 10m.
What companies run services between Natick, MA, USA and Eastham, MA, USA?
Cape Flyer operates a train from South Station to Hyannis 3 times a week. Tickets cost $5–22 and the journey takes 2h 30m. Alternatively, you can take a train from Natick Center to Eastham via Framingham, Framingham, Boston, Boston South Buses, and Hyannis Transportation Center in around 6h 10m.
Train from Natick Center to South Station
- Ave. Duration
- 46 min
- Frequency
- Hourly
- Estimated price
- $3–9
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $3–9
Train from Natick Center to South Station
- Ave. Duration
- 46 min
- Frequency
- Hourly
- Estimated price
- $3–9
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $3–9
Train from Natick Center to South Station
- Ave. Duration
- 46 min
- Frequency
- Hourly
- Estimated price
- $3–9
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $3–9
- Phone
- +1 508-775-8504
- [email protected]
- Website
- CapeFlyer
Train from South Station to Hyannis
- Ave. Duration
- 2h 30m
- Frequency
- 3 times a week
- Estimated price
- $5–22
- Website
- CapeFlyer
- South Station to Bourne
- $20
- South Station to Hyannis
- $22
- Middleborough to Hyannis
- $5
- Phone
- +1 (508) 746-0378
- [email protected]
- Website
- Plymouth & Brockton
Bus from Boston South Buses to Hyannis Transportation Center
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
Bus from Boston South Buses to Hyannis Transportation Center
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
- Phone
- 1-800-343-9999
- Website
- Peter Pan
Bus from Hyannis Transportation Center to Eastham
- Ave. Duration
- 40 min
- Frequency
- 5 times a day
- Estimated price
- $5–13
- Website
- Peter Pan
Bus from Boston South Station to Hyannis Transportation Center
- Ave. Duration
- 1h 35m
- Frequency
- Every 3 hours
- Estimated price
- $15–40
- Website
- Peter Pan
Bus from Hyannis Transportation Center to Eastham
- Ave. Duration
- 40 min
- Frequency
- 5 times a day
- Estimated price
- $5–13
- Website
- Peter Pan
Bus from Boston to Hyannis
- Ave. Duration
- 1h 40m
- Frequency
- Every 3 hours
- Estimated price
- $15–40
- Website
- Peter Pan
Bus from Hyannis Transportation Center to Eastham
- Ave. Duration
- 40 min
- Frequency
- 5 times a day
- Estimated price
- $5–13
- Website
- Peter Pan
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Framingham to Boston
- Ave. Duration
- 50 min
- Frequency
- Once daily
- Estimated price
- $3–6
- Website
- Greyhound
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More Questions & Answers
Natick to Eastham bus services, operated by Greyhound USA, arrive at Boston station.
Natick to Eastham train services, operated by Cape Flyer, arrive at Hyannis station.
Yes, the driving distance between Natick to Eastham is 102 miles. It takes approximately 2h 9m to drive from Natick to Eastham.
There are 724+ hotels available in Eastham.












