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How to get fromNatick to Syracuseby bus (Greyhound, Flixbus), train (Amtrak), car, train, plane, or bus

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There are 7 ways to get from Natick to Syracuse by bus (Greyhound, Flixbus), train (Amtrak), car, train, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Framingham to Springfield Union Stationbus bus Greyhound US0270s
    2. Take the bus from Springfield Union Station to Syracuse Bus Stationbus bus Greyhound US0171 / ...
    8h 23m
    $42–93

  2. Train (Amtrak)

    1. Take the train from Framingham Amtrak to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    9h 34m
    $101–226

  3. Drive 294.7 mi

    1. Drive from Natick to Syracusecar car 294.7 mi
    5h 12m
    $54–78

  4. Train, fly to Syracuse Hancock International Airport

    1. Take the train from Natick Center to Back Baytrain train
    2. Fly from Boston Logan Airport (BOS) to Syracuse Hancock International Airport (SYR)plane plane BOS - SYR
    5h 22m
    $98–576

  5. Train, bus

    1. Take the train from Natick Center to Worcestertrain train
    2. Take the bus from Worcester Union Station to Albany Bus Terminal, NYbus bus
    3. Take the bus from Albany to Syracusebus bus
    9h 44m
    $51–128

  6. Fly to Rochester, train

    1. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    6h 20m
    $136–760

  7. Fly to Buffalo Niagara International Airport, bus

    1. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    2. Take the bus from Buffalo Niagara International Airport to Syracuse Bus Stationbus bus
    7h 27m
    $119–608

Natick to Syracuse by train and bus

Calendar14Weekly Services
Duration8h 23mAverage Duration
Ticket$42Cheapest Price
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Questions & Answers

Map of how to get from Natick to Syracuse.ExpandLaunch map view
  • Distance: 306.4 mi
  • Duration: 8h 23m

What companies run services between Natick, MA, USA and Syracuse, NY, USA?

You can take a train from Natick Center to Syracuse Bus Station via Framingham, Framingham, and Springfield Union Station in around 8h 23m. Alternatively, Amtrak operates a train from Framingham Amtrak to Syracuse Regional Transportation Center once daily. Tickets cost $100–220 and the journey takes 8h 26m.

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