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How to get fromNew Castle to Knoxvilleby train, plane, bus, car, or subway

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There are 10 ways to get from New Castle to Knoxville by train, plane, bus, car, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the train from Wilmington to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    5h 27m
    $226–1,577

  2. Drive 580.2 mi

    cheapest
    1. Drive from New Castle to Knoxvillecar car 580.2 mi
    10h 11m
    $106–153

  3. Train, bus

    1. Take the train from Wilmington to Ny Moynihan Train Hall At Penn Stationtrain train Northeast Regional / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    16h 13m
    $166–815

  4. Train to Baltimore-Washington International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Wilmington to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS)plane plane BWI - TYS
    5h 23m
    $206–1,474

  5. Train to Ronald Reagan Washington National Airport, fly to Mcghee Tyson Airport

    1. Take the train from Wilmington to New Carrollton Amtrak Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Mcghee Tyson Airport (TYS)plane plane DCA - TYS
    6h 44m
    $272–1,245

  6. Train, subway to Washington Dulles International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Wilmington to New Carrollton Amtrak Stationtrain train
    2. Take the subway from New Carrollton, Orange Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to Mcghee Tyson Airport (TYS)plane plane IAD - TYS
    7h 20m
    $190–792

  7. Train to Philadelphia International Airport, fly to Asheville Regional Airport, drive

    1. Take the train from Wilmington to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Asheville Regional Airport (AVL)plane plane PHL - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 25m
    $113–1,062

  8. Train to Laguardia Airport, fly to Mcghee Tyson Airport

    1. Take the train from Wilmington to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Mcghee Tyson Airport (TYS)plane plane LGA - TYS
    7h 53m
    $262–1,691

  9. Train, bus via Farragut

    1. Take the train from Wilmington to Ny Moynihan Train Hall At Penn Stationtrain train Northeast Regional / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    16h 35m
    $212–907

  10. Bus

    1. Take the bus from Wilmington, DE - 3 W 4th St. to Chinatown-152 East Broadwaybus bus New York to Wilmington
    2. Take the bus from New York to Knoxvillebus bus Nyc
    17h 50m
    $210–299

Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS) flights

Calendar74Weekly Planes
Duration3h 32mAverage Duration
Ticket$169Cheapest Price
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Questions & Answers

Map of how to get from New Castle to Knoxville.ExpandLaunch map view
  • Distance: 610.5 mi
  • Duration: 5h 27m

What companies run services between New Castle, DE, USA and Knoxville, TN, USA?

You can take a bus from 6Th St @ Delaware St to Knoxville via Delaware Ave @ Adams St, King St @ 3Rd St, Wilmington, DE - 3 W 4th St., Chinatown-152 East Broadway, New York, and Knoxville in around 17h 50m.

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