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How to get fromNew Castle to Chicagoby bus, plane, train, bus (Greyhound, Flixbus), car, or bus (Flixbus)

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There are 8 ways to get from New Castle to Chicago by bus, plane, train, bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Transit Center, PA to East Busway At Penn Station Dbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    6h 7m
    $66–377

  2. Bus to Erie International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from New Castle Park & Ride to Eriebus bus
    2. Fly from Erie International Airport (ERI) to Chicago O'Hare International Airport (ORD)plane plane ERI - ORD
    8h 59m
    $65–310

  3. Bus, train

    1. Take the bus from Transit Center, PA to East Busway At Penn Station Dbus bus Pittsburgh Inbound
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    12h 16m
    $154–332

  4. Bus

    1. Take the bus from Transit Center, PA to East Busway At Penn Station Dbus bus Pittsburgh Inbound
    2. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus Greyhound US0164
    12h 35m
    $74–152

  5. Drive 419 mi

    1. Drive from New Castle to Chicagocar car 419 mi
    7h 1m
    $77–111

  6. Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Transit Center, PA to East Busway At Penn Station Dbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    6h 34m
    $386–1,217

  7. Bus to Akron, fly to Chicago O'Hare International Airport

    1. Take the bus from Youngstown Bus Stop to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Chicago O'Hare International Airport (ORD)plane plane CAK - ORD
    6h 19m
    $103–373

  8. Bus via Chicago

    1. Take the bus from Transit Center, PA to East Busway At Penn Station Dbus bus Pittsburgh Inbound
    2. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    13h 52m
    $91–157

Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW) flights

Calendar22Weekly Planes
Duration1h 35mAverage Duration
Ticket$61Cheapest Price
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Questions & Answers

Map of how to get from New Castle to Chicago.ExpandLaunch map view
  • Distance: 489.7 mi
  • Duration: 6h 7m

What companies run services between New Castle, Lawrence County, PA, USA and Chicago, IL, USA?

You can take a bus from Transit Center, PA to Chicago Bus Station via East Busway At Penn Station D and Pittsburgh Intermodal Station in around 12h 35m.

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