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How to get fromNew Castle to St. Louisby bus, plane, bus (Greyhound), train, or car

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There are 4 ways to get from New Castle to St. Louis by bus, plane, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly

    best
    1. Take the bus from Transit Center, PA to East Busway At Penn Station Dbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    6h 29m
    $107–615

  2. Bus

    cheapest
    1. Take the bus from Transit Center, PA to East Busway At Penn Station Dbus bus Pittsburgh Inbound
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    15h 25m
    $94–192

  3. Bus, train

    1. Take the bus from Transit Center, PA to East Busway At Penn Station Dbus bus
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    18h 2m
    $239–522

  4. Drive 601.6 mi

    1. Drive from New Castle to St. Louiscar car 601.6 mi
    10h 20m
    $110–159

Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL) flights

Calendar53Weekly Planes
Duration3h 21mAverage Duration
Ticket$107Cheapest Price
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Questions & Answers

Map of how to get from New Castle to St. Louis.ExpandLaunch map view
  • Distance: 644.4 mi
  • Duration: 6h 29m

What companies run services between New Castle, Lawrence County, PA, USA and St. Louis, MO, USA?

You can take a bus from Transit Center, PA to St Louis Bus Station via East Busway At Penn Station D and Pittsburgh Intermodal Station in around 15h 25m.

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