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How to get fromNew Orleans to Florenceby plane, bus (Greyhound), train, bus, car, or train (Amtrak)

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There are 5 ways to get from New Orleans to Florence by plane, bus (Greyhound), train, bus, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Louis Armstrong New Orleans International Airport (MSY) to Florence Regional Airport (FLO)plane plane MSY - FLO
    5h 49m
    $107–515

  2. Bus (Greyhound)

    1. Take the bus from New Orleans Bus Station to Atlanta Bus Stationbus bus Greyhound US0602
    2. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus Greyhound US0641S / ...
    15h 50m
    $117–220

  3. Train, bus

    1. Take the train from New Orleans Union Passenger Terminal to Charlotte Amtrak Stationtrain train
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    24h 2m
    $269–553

  4. Drive 752.3 mi

    1. Drive from New Orleans to Florencecar car 752.3 mi
    12h 19m
    $138–199

  5. Train (Amtrak)

    1. Take the train from New Orleans Union Passenger Terminal to Greensborotrain train
    2. Take the train from Greensboro to Selma Stationtrain train
    3. Take the train from Selma Station to Florence Stationtrain train
    28h 14m
    $352–736

New Orleans to Florence by bus (Greyhound)

Calendar28Weekly Buses
Duration15h 50mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

Map of how to get from New Orleans to Florence.ExpandLaunch map view
  • Distance: 695.6 mi
  • Duration: 5h 49m

What companies run services between New Orleans, LA, USA and Florence, SC, USA?

American Airlines flies from Louis Armstrong New Orleans International Airport (MSY) to Florence Regional Airport (FLO) 3 times a day. Alternatively, you can take a bus from New Orleans Bus Station to Florence Bus Station via Atlanta Bus Station in around 15h 50m.

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