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How to get fromNew Orleans to Knoxvilleby plane, train, bus, shuttle, or car

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There are 6 ways to get from New Orleans to Knoxville by plane, train, bus, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louis Armstrong New Orleans International Airport to Mcghee Tyson Airport

    best
    1. Fly from Louis Armstrong New Orleans International Airport (MSY) to Mcghee Tyson Airport (TYS)plane plane MSY - TYS
    5h 20m
    $197–872

  2. Fly Louis Armstrong New Orleans International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Louis Armstrong New Orleans International Airport (MSY) to Asheville Regional Airport (AVL)plane plane MSY - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 38m
    $109–497

  3. Train, bus, shuttle, drive

    1. Take the train from New Orleans Union Passenger Terminal to Charlotte Amtrak Stationtrain train
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    28h 44m
    $582–869

  4. Drive 598.2 mi

    1. Drive from New Orleans to Knoxvillecar car 598.2 mi
    9h 46m
    $110–158

  5. Train to Gulfport-Biloxi Regional Airport, fly to Mcghee Tyson Airport

    1. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Mcghee Tyson Airport (TYS)plane plane GPT - TYS
    6h 5m
    $221–932

  6. Fly Louis Armstrong New Orleans International Airport to Nashville, drive

    1. Fly from Louis Armstrong New Orleans International Airport (MSY) to Nashville (BNA)plane plane MSY - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 2m
    $582–1,052

Louis Armstrong New Orleans International Airport (MSY) to Mcghee Tyson Airport (TYS) flights

Calendar65Weekly Planes
Duration4hAverage Duration
Ticket$148Cheapest Price
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Questions & Answers

Map of how to get from New Orleans to Knoxville.ExpandLaunch map view
  • Distance: 567 mi
  • Duration: 5h 20m

What companies run services between New Orleans, LA, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and American Airlines fly from Louis Armstrong New Orleans International Airport (MSY) to Mcghee Tyson Airport (TYS) every 3 hours.

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