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How to get fromNew Orleans to Lexingtonby plane, bus (Greyhound), train, bus, or car

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There are 6 ways to get from New Orleans to Lexington by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louis Armstrong New Orleans International Airport to Columbia

    best
    1. Fly from Louis Armstrong New Orleans International Airport (MSY) to Columbia (CAE)plane plane MSY - CAE
    5h 30m
    $230–1,137

  2. Drive 662.7 mi

    cheapest
    1. Drive from New Orleans to Lexingtoncar car 662.7 mi
    10h 46m
    $121–175

  3. Bus

    1. Take the bus from New Orleans Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    16h 25m
    $167–291

  4. Train, bus

    1. Take the train from New Orleans Union Passenger Terminal to Charlotte Amtrak Stationtrain train
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    23h 30m
    $337–621

  5. Train to Gulfport-Biloxi Regional Airport, fly to Columbia

    1. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Columbia (CAE)plane plane GPT - CAE
    6h
    $245–1,197

  6. Fly Louis Armstrong New Orleans International Airport to Charleston International Airport, drive

    1. Fly from Louis Armstrong New Orleans International Airport (MSY) to Charleston International Airport (CHS)plane plane MSY - CHS
    2. Drive from Charleston-Airport-CHS to Lexingtoncar car
    5h 30m
    $122–512

Louis Armstrong New Orleans International Airport (MSY) to Columbia (CAE) flights

Calendar101Weekly Planes
Duration5h 5mAverage Duration
Ticket$204Cheapest Price
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Questions & Answers

Map of how to get from New Orleans to Lexington.ExpandLaunch map view
  • Distance: 621.6 mi
  • Duration: 5h 30m

What companies run services between New Orleans, LA, USA and Lexington, SC, USA?

Delta, American Airlines, and United Airlines fly from Louis Armstrong New Orleans International Airport (MSY) to Columbia (CAE) hourly. Alternatively, you can take a bus from New Orleans Bus Station to Lexington via Atlanta Bus Station, Camden, and Columbia, SC in around 16h 25m.

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