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How to get fromNew Orleans to Louisvilleby plane, bus (Greyhound, Amtrak), train, bus, car, or bus (Greyhound)

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There are 7 ways to get from New Orleans to Louisville by plane, bus (Greyhound, Amtrak), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louis Armstrong New Orleans International Airport to Louisville International Airport

    best
    1. Fly from Louis Armstrong New Orleans International Airport (MSY) to Louisville International Airport (SDF)plane plane MSY - SDF
    4h 48m
    $223–705

  2. Bus

    cheapest
    1. Take the bus from New Orleans Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    16h 45m
    $118–225

  3. Train, bus

    1. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    23h 10m
    $301–610

  4. Drive 704.7 mi

    1. Drive from New Orleans to Louisvillecar car 704.7 mi
    11h 26m
    $129–186

  5. Fly Louis Armstrong New Orleans International Airport to Blue Grass Airport, drive

    1. Fly from Louis Armstrong New Orleans International Airport (MSY) to Blue Grass Airport (LEX)plane plane MSY - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 41m
    $215–1,121

  6. Train to Gulfport-Biloxi Regional Airport, fly to Louisville International Airport

    1. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Louisville International Airport (SDF)plane plane GPT - SDF
    7h 44m
    $167–766

  7. Bus via Preston @ Vim

    1. Take the bus from New Orleans Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Nashville Bus Stationbus bus
    3. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    17h 36m
    $141–330

New Orleans to Louisville by bus

Calendar14Weekly Buses
Duration16h 45mAverage Duration
Ticket$118Cheapest Price
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Questions & Answers

Map of how to get from New Orleans to Louisville.ExpandLaunch map view
  • Distance: 640.9 mi
  • Duration: 4h 48m

What companies run services between New Orleans, LA, USA and Louisville, KY, USA?

Breeze Airways, Southwest Airlines, and two other airlines fly from Louis Armstrong New Orleans International Airport (MSY) to Louisville International Airport (SDF) 5 times a day. Alternatively, you can take a bus from New Orleans Bus Station to Louisville, KY via Montgomery Intermodal Center and Nashville in around 16h 45m.

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