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How to get fromNew Smyrna Beach to Mayo Clinicby plane, bus, bus (Greyhound, Flixbus), taxi, train, car, or shuttle

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There are 10 ways to get from New Smyrna Beach to Mayo Clinic by plane, bus, bus (Greyhound, Flixbus), taxi, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Daytona Beach International Airport to Minneapolis–Saint Paul International Airport, bus

    best
    1. Fly from Daytona Beach International Airport (DAB) to Minneapolis–Saint Paul International Airport (MSP)plane plane DAB - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    11h 50m
    $238–908

  2. Train to Orlando, fly to Rochester

    cheapest
    1. Take the train from DeLand to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Rochester (RST)plane plane MCO - RST
    14h 52m
    $114–525

  3. Bus

    1. Take the bus from New Smyrna Beach to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    5. Take the bus from Milwaukee to Rochesterbus bus
    36h 45m
    $266–490

  4. Taxi, train, bus via Madison

    1. Take the taxi from New Smyrna Beach to Delandtaxi taxi
    2. Take the train from Deland to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    2d
    $638–1,304

  5. Drive 1,412.9 mi

    1. Drive from New Smyrna Beach to Mayo Cliniccar car 1,412.9 mi
    25h 17m
    $258–373

  6. Bus to Jacksonville, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from New Smyrna Beach to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Minneapolis–Saint Paul International Airport (MSP)plane plane JAX - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    11h 8m
    $221–799

  7. Train to Orlando, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from DeLand to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCO - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    14h 23m
    $265–1,167

  8. Taxi to Orlando Sanford, fly to La Crosse, bus

    1. Take the taxi from New Smyrna Beach to Orlando-Sanford-Airport-SFBtaxi taxi
    2. Fly from Orlando Sanford (SFB) to La Crosse (LSE)plane plane SFB - LSE
    3. Take the bus from Landline - La Crosse Regional Airport to Landline - MSP Terminal-2 Humphreybus bus
    4. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 13m
    $263–686

  9. Taxi to Orlando Sanford, fly to Des Moines, shuttle, bus

    1. Take the taxi from New Smyrna Beach to Orlando-Sanford-Airport-SFBtaxi taxi
    2. Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane plane SFB - DSM
    3. Take a shuttle bus from Des Moines International Airport, IA to Ames, IA - Iowa State Universityshuttle bus
    4. Take the bus from Ames to Owatonnabus bus
    5. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    10h 39m
    $368–1,181

  10. Taxi, train, bus

    1. Take the taxi from New Smyrna Beach to Delandtaxi taxi
    2. Take the train from Deland to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    2d 1h
    $711–1,484

Daytona Beach International Airport (DAB) to Minneapolis–Saint Paul International Airport (MSP) flights

Calendar43Weekly Planes
Duration6h 29mAverage Duration
Ticket$187Cheapest Price
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Questions & Answers

Map of how to get from New Smyrna Beach to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,377.7 mi
  • Duration: 11h 50m

What companies run services between New Smyrna Beach, FL, USA and Mayo Clinic, MN, USA?

You can take a vehicle from New Smyrna Beach to Mayo Clinic via New Smyrna Beach, Jacksonville, Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 36h 45m.

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