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How to get fromNew York to Uptownby subway, bus, plane, train (Amtrak), bus (Flixbus), car, train, or bus (Greyhound, Amtrak)

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There are 10 ways to get from New York to Uptown by subway, bus, plane, train (Amtrak), bus (Flixbus), car, train, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 4 subway, bus to Laguardia Airport, fly to Chicago Midway International Airport, subway

    best
    1. Take the subway from 14 St-Union Sq to 125th Streetsubway subway
    2. Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus bus
    3. Fly from Laguardia Airport (LGA) to Chicago Midway International Airport (MDW)plane plane LGA - MDW
    4. Take the subway from Roosevelt to Wilson-North Innersubway subway
    5h 16m
    $210–671

  2. Train to Westchester County Airport, fly to Chicago O'Hare International Airport, subway

    cheapest
    1. Take the train from Grand Central Terminal to White Plainstrain train
    2. Fly from Westchester County Airport (HPN) to Chicago O'Hare International Airport (ORD)plane plane HPN - ORD
    3. Take the subway from Lake to Wilson-North Innersubway subway
    7h 20m
    $116–627

  3. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train Lake Shore Limited / ...
    20h 33m
    $266–669

  4. Bus (Flixbus)

    1. Take the bus from New York City Chinatown to Chicago Bus Stationbus bus FlixBus N2640
    22h 18m
    $157–231

  5. Drive  795.2 mi

    1. Drive from New York to Uptowncar car 795.2 mi
    13h 20m
    $146–210

  6. Fly Newark Liberty International Airport to Chicago O'Hare International Airport

    1. Fly from Newark Liberty International Airport (EWR) to Chicago O'Hare International Airport (ORD)plane plane EWR - ORD
    5h 18m
    $145–887

  7. Line 4 subway, bus to Laguardia Airport, fly to Chicago O'Hare International Airport, subway

    1. Take the subway from 14 St-Union Sq to 125th Streetsubway subway
    2. Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus bus
    3. Fly from Laguardia Airport (LGA) to Chicago O'Hare International Airport (ORD)plane plane LGA - ORD
    4. Take the subway from Lake to Wilson-North Innersubway subway
    5h 31m
    $140–571

  8. Fly John F. Kennedy International Airport to Chicago O'Hare International Airport

    1. Fly from John F. Kennedy International Airport (JFK) to Chicago O'Hare International Airport (ORD)plane plane JFK - ORD
    5h 31m
    $328–878

  9. Fly Laguardia Airport to General Mitchell International Airport, bus

    1. Fly from Laguardia Airport (LGA) to General Mitchell International Airport (MKE)plane plane LGA - MKE
    2. Take the bus from Mitchell Airport to O'Hare International Airport - Terminal 2 Departuresbus bus
    7h 45m
    $185–860

  10. Bus via Toledo

    1. Take the bus from Port Authority Bus Terminal to Toledo Bus Stopbus bus Greyhound US0420
    2. Take the bus from Toledo to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    22h 33m
    $165–254

New York to Uptown by train and bus (Amtrak)

Calendar10Weekly Services
Duration20h 33mAverage Duration
Ticket$266Cheapest Price
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Comparing Your Travel Options

Map of how to get from New York to Uptown.ExpandLaunch map view
  • Distance: 753.6 mi
  • Duration: 5h 16m

What companies run services between New York, NY, USA and Uptown, IL, USA?

Amtrak operates a train from Ny Moynihan Train Hall At Penn Station to Chicago Union Station once daily. Tickets cost $260–700 and the journey takes 19h 32m. Alternatively, Flixbus USA operates a bus from New York City Chinatown to Chicago Bus Station 6 times a week. Tickets cost $150–230 and the journey takes 21h 10m.

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