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How to get fromNew York to Uptownby subway, bus, plane, train (Amtrak), bus (Flixbus), car, train, or bus (Greyhound)

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There are 10 ways to get from New York to Uptown by subway, bus, plane, train (Amtrak), bus (Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 4 subway, bus to Laguardia Airport, fly to Chicago Midway International Airport, subway

    best
    1. Take the subway from 14 St-Union Sq to 125th Streetsubway subway
    2. Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus bus
    3. Fly from Laguardia Airport (LGA) to Chicago Midway International Airport (MDW)plane plane LGA - MDW
    4. Take the subway from Roosevelt to Wilson-North Innersubway subway
    5h 14m
    $190–571

  2. Train to Westchester County Airport, fly to Chicago O'Hare International Airport, subway

    cheapest
    1. Take the train from Grand Central Terminal to White Plainstrain train
    2. Fly from Westchester County Airport (HPN) to Chicago O'Hare International Airport (ORD)plane plane HPN - ORD
    3. Take the subway from Lake to Wilson-North Innersubway subway
    7h 14m
    $106–477

  3. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train Lake Shore Limited / ...
    20h 37m
    $315–627

  4. Bus

    1. Take the bus from New York City Chinatown to Chicago Bus Stationbus bus FlixBus N2640
    22h 22m
    $165–266

  5. Drive 795.2 mi

    1. Drive from New York to Uptowncar car 795.2 mi
    13h 20m
    $146–210

  6. Fly Newark Liberty International Airport to Chicago O'Hare International Airport

    1. Fly from Newark Liberty International Airport (EWR) to Chicago O'Hare International Airport (ORD)plane plane EWR - ORD
    5h 17m
    $184–887

  7. Line 4 subway, bus to Laguardia Airport, fly to Chicago O'Hare International Airport, subway

    1. Take the subway from 14 St-Union Sq to 125th Streetsubway subway
    2. Take the bus from E 125 St/Lexington Av to Laguardia Rd/94 Stbus bus
    3. Fly from Laguardia Airport (LGA) to Chicago O'Hare International Airport (ORD)plane plane LGA - ORD
    4. Take the subway from Lake to Wilson-North Innersubway subway
    5h 32m
    $220–671

  8. Fly John F. Kennedy International Airport to Chicago O'Hare International Airport

    1. Fly from John F. Kennedy International Airport (JFK) to Chicago O'Hare International Airport (ORD)plane plane JFK - ORD
    5h 25m
    $328–878

  9. Fly Laguardia Airport to General Mitchell International Airport, bus

    1. Fly from Laguardia Airport (LGA) to General Mitchell International Airport (MKE)plane plane LGA - MKE
    2. Take the bus from Mitchell Airport to O'Hare International Airport - Terminal 2 Departuresbus bus
    7h 27m
    $175–760

  10. Bus via Baltimore

    1. Take the bus from Port Authority Bus Terminal to Baltimorebus bus New York
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    24h 37m
    $151–304

New York to Uptown by train and bus (Amtrak)

Calendar10Weekly Services
Duration20h 37mAverage Duration
Ticket$315Cheapest Price
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Questions & Answers

Map of how to get from New York to Uptown.ExpandLaunch map view
  • Distance: 753.6 mi
  • Duration: 5h 14m

What companies run services between New York, NY, USA and Uptown, IL, USA?

Amtrak operates a train from Ny Moynihan Train Hall At Penn Station to Chicago Union Station once daily. Tickets cost $310–650 and the journey takes 19h 32m. Alternatively, FlixBus-us operates a bus from New York City Chinatown to Chicago Bus Station once daily, and the journey takes 21h 10m. Flixbus USA also services this route 6 times a week.

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