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How to get fromNiagara Falls to St. Louisby bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus)

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There are 7 ways to get from Niagara Falls to St. Louis by bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 13m
    $148–761

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Columbus - Mound Stbus bus Buffalo
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    19h 11m
    $97–212

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    18h 5m
    $269–684

  4. Drive 753.7 mi

    1. Drive from Niagara Falls to St. Louiscar car 753.7 mi
    13h 1m
    $173–250

  5. Train to Rochester, fly

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    7h 13m
    $188–941

  6. Train to Toronto Pearson International Airport, fly

    1. Take the train from Niagara Falls to Toronto Union Stationtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    7h 25m
    $115–644

  7. Bus via Auburn Gresham

    1. Take the bus from Niagara Falls, ON to Toronto Union Stationbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicagobus bus
    4. Take the bus from Chicago to St Louis Bus Stationbus bus
    24h 45m
    $152–304

Niagara Falls to St. Louis by train

Calendar14Weekly Trains
Duration18h 5mAverage Duration
Ticket$269Cheapest Price
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Questions & Answers

Map of how to get from Niagara Falls to St. Louis.ExpandLaunch map view
  • Distance: 718 mi
  • Duration: 6h 13m

What companies run services between Niagara Falls, ON, Canada and St. Louis, MO, USA?

You can take a train from Niagara Falls Amtrak Station to St. Louis via Buffalo Depew Station and Chicago Union Station in around 18h 5m. Alternatively, you can take a bus from Main Street & Walnut Avenue to St Louis Bus Station via Buffalo, NY and Columbus in around 19h 11m.

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