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How to get fromNiagara Falls Station to Chicagoby bus, plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus (Flixbus)

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There are 10 ways to get from Niagara Falls Station to Chicago by bus, plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    5h 43m
    $189–325

  2. Bus

    cheapest
    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicagobus bus
    18h 9m
    $99–160

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    12h 19m
    $299–593

  4. Bus via Brook Park

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Chicago Union Stationbus bus
    13h 45m

  5. Drive  518.4 mi

    1. Drive from Niagara Falls Station to Chicagocar car 518.4 mi
    8h 46m
    $107–154

  6. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    5h 32m
    $141–792

  7. Train to Rochester, fly to Chicago O'Hare International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    5h 46m
    $116–602

  8. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    6h 2m
    $179–315

  9. Train to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Canadian Border to Torontotrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    8h 1m
    $418–1,025

  10. Train to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Canadian Border to Torontotrain train
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    7h 56m
    $249–1,489

Niagara Falls Station to Chicago by train

Calendar14Weekly Trains
Duration12h 19mAverage Duration
Ticket$299Cheapest Price
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Comparing Your Travel Options

Map of how to get from Niagara Falls Station to Chicago.ExpandLaunch map view
  • Distance: 511.7 mi
  • Duration: 5h 43m

What companies run services between Niagara Falls Station, NY, USA and Chicago, IL, USA?

You can take a train from Niagara Falls Amtrak Station to Chicago Union Station via Buffalo Depew Station in around 12h 19m. Alternatively, you can take a vehicle from Niagara Falls Station to Chicago Union Station via Portage Road & NF Transportation Center, Ellicott Street & MTC Static, Buffalo, Cleveland Bus Station, and Toledo in around 13h 45m.

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