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How to get fromNiagara Falls to Chicago Bus Stationby bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus, Amtrak)

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There are 10 ways to get from Niagara Falls to Chicago Bus Station by bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    4h 21m
    $107–443

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    13h 42m
    $82–172

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    12h 28m
    $179–494

  4. Drive 521.1 mi

    1. Drive from Niagara Falls to Chicago Bus Stationcar car 521.1 mi
    8h 44m
    $96–138

  5. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    4h 41m
    $157–383

  6. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    5h 27m
    $126–633

  7. Train to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Canadian Border to Torontotrain train
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    7h 7m
    $199–1,359

  8. Train to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Niagara Falls to Toronto Union Stationtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    7h 27m
    $354–1,266

  9. Train to Toronto Island Airport, fly to Chicago Midway International Airport

    1. Take the train from Canadian Border to Torontotrain train
    2. Fly from Toronto Island Airport (YTZ) to Chicago Midway International Airport (MDW)plane plane YTZ - MDW
    7h 1m
    $169–489

  10. Bus via Detroit

    1. Take the bus from Niagara Falls, ON to Toronto Union Stationbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit to Chicago Union Stationbus bus
    17h 16m
    $142–259

Niagara Falls to Chicago Bus Station by train and foot

Calendar14Weekly Services
Duration12h 28mAverage Duration
Ticket$179Cheapest Price
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Questions & Answers

Map of how to get from Niagara Falls to Chicago Bus Station.ExpandLaunch map view
  • Distance: 509.7 mi
  • Duration: 4h 21m

What companies run services between Niagara Falls, NY, USA and Chicago Bus Station, IL, USA?

You can take a train from Niagara Falls Amtrak Station to Chicago Bus Station via Buffalo Depew Station and Chicago Union Station in around 12h 28m. Alternatively, you can take a bus from Pine Avenue & Main Street to Chicago Bus Station via Ellicott Street & MTC Static, Buffalo, and Cleveland Bus Station in around 13h 42m.

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Need to know: Greyhound

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