Rome2Rio

How to get fromNiagara Falls to Des Moinesby bus, plane, train, bus (Greyhound), car, or bus (Flixbus, Amtrak, Greyhound)

Find Transport to Des Moines

See all options

There are 8 ways to get from Niagara Falls to Des Moines by bus, plane, train, bus (Greyhound), car, or bus (Flixbus, Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    6h 35m
    $103–460

  2. Bus to Toronto Pearson International Airport, fly

    cheapest
    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Des Moines (DSM)plane plane YYZ - DSM
    9h 26m
    $94–398

  3. Train, bus via Galesburg

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    21h 50m
    $409–792

  4. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    23h 7m
    $157–247

  5. Drive  832.1 mi

    1. Drive from Niagara Falls to Des Moinescar car 832.1 mi
    13h 57m
    $143–206

  6. Train to Rochester, fly

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Des Moines (DSM)plane plane ROC - DSM
    7h 22m
    $172–858

  7. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S / ...
    24h 35m
    $346–551

  8. Bus via Dearborn

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Dearborn to Chicago Union Stationbus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    26h 52m

Niagara Falls to Des Moines by train and bus

Calendar14Weekly Services
Duration21h 50mAverage Duration
Ticket$409Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Niagara Falls to Des Moines.ExpandLaunch map view
  • Distance: 806 mi
  • Duration: 6h 35m

What companies run services between Niagara Falls, NY, USA and Des Moines, IA, USA?

You can take a bus from Pine Avenue & Main Street to Des Moines via Ellicott Street & MTC Static, Buffalo, Cleveland Bus Station, and Chicago Bus Station in around 23h 7m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There