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How to get fromNiagara Falls to Des Moinesby bus, plane, train, bus (Greyhound), car, or bus (Flixbus, Amtrak, Greyhound)

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There are 9 ways to get from Niagara Falls to Des Moines by bus, plane, train, bus (Greyhound), car, or bus (Flixbus, Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    5h 51m
    $202–929

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    21h 12m
    $137–272

  3. Train, bus

    1. Take the train from Canadian Border to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    21h 1m
    $231–472

  4. Drive 835.3 mi

    1. Drive from Niagara Falls to Des Moinescar car 835.3 mi
    13h 56m
    $153–221

  5. Train to Rochester, fly

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Des Moines (DSM)plane plane ROC - DSM
    7h 2m
    $241–1,109

  6. Train to Toronto Pearson International Airport, fly

    1. Take the train from Niagara Falls to Toronto Union Stationtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Des Moines (DSM)plane plane YYZ - DSM
    9h 2m
    $149–781

  7. Train to Toronto Island Airport, fly

    1. Take the train from Canadian Border to Torontotrain train
    2. Fly from Toronto Island Airport (YTZ) to Des Moines (DSM)plane plane YTZ - DSM
    8h 27m
    $164–725

  8. Train, bus via Galesburg

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    21h 50m
    $259–669

  9. Bus via Detroit

    1. Take the bus from Niagara Falls, ON to Toronto Union Stationbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit to Chicago Union Stationbus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    24h 46m
    $187–359

Niagara Falls to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration21h 1mAverage Duration
Ticket$231Cheapest Price
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Questions & Answers

Map of how to get from Niagara Falls to Des Moines.ExpandLaunch map view
  • Distance: 806 mi
  • Duration: 5h 51m

What companies run services between Niagara Falls, NY, USA and Des Moines, IA, USA?

You can take a bus from Pine Avenue & Main Street to Des Moines via Ellicott Street & MTC Static, Buffalo, Cleveland Bus Station, and Chicago Bus Station in around 21h 12m.

Airlines
Train operators
Bus operators

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