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How to get fromNiagara Falls to Des Moinesby bus, plane, bus (Greyhound), train, car, or bus (Flixbus, Amtrak, Greyhound)

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There are 9 ways to get from Niagara Falls to Des Moines by bus, plane, bus (Greyhound), train, car, or bus (Flixbus, Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    6h 21m
    $103–460

  2. Bus to Toronto Pearson International Airport, fly

    cheapest
    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Des Moines (DSM)plane plane YYZ - DSM
    9h 3m
    $90–436

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    21h 12m
    $132–222

  4. Train, bus via Galesburg

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    21h 50m
    $194–591

  5. Drive  832.1 mi

    1. Drive from Niagara Falls to Des Moinescar car 832.1 mi
    13h 56m
    $152–220

  6. Train to Rochester, fly

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Des Moines (DSM)plane plane ROC - DSM
    7h 17m
    $172–857

  7. Bus to Toronto Island Airport, fly

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Island Airport (YTZ) to Des Moines (DSM)plane plane YTZ - DSM
    9h 22m
    $95–466

  8. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    22h 40m
    $176–391

  9. Bus via Dearborn

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Dearborn to Chicago Union Stationbus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    24h 52m
    $159–290

Niagara Falls to Des Moines by bus (Greyhound)

Calendar14Weekly Buses
Duration21h 12mAverage Duration
Ticket$132Cheapest Price
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Comparing Your Travel Options

Map of how to get from Niagara Falls to Des Moines.ExpandLaunch map view
  • Distance: 806 mi
  • Duration: 6h 21m

What companies run services between Niagara Falls, NY, USA and Des Moines, IA, USA?

You can take a bus from Pine Avenue & Main Street to Des Moines via Ellicott Street & MTC Static, Buffalo, Cleveland Bus Station, and Chicago Bus Station in around 21h 12m.

Airlines
Train operators
Bus operators

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