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How to get fromNiagara Falls to Florenceby bus, plane, bus (Flixbus), train (Amtrak), car, or train

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There are 6 ways to get from Niagara Falls to Florence by bus, plane, bus (Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Florence Regional Airport (FLO)plane plane BUF - FLO
    5h 54m
    $110–572

  2. Bus

    1. Take the bus from Niagara Falls USA to New York Midtownbus bus FlixBus N2686 / ...
    2. Take the bus from New York, NY to Florence, SCbus bus Nyc
    22h 49m
    $168–265

  3. Train (Amtrak)

    1. Take the train from Niagara Falls Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    24h 34m
    $352–726

  4. Drive 743.8 mi

    1. Drive from Niagara Falls to Florencecar car 743.8 mi
    15h 14m
    $136–197

  5. Train via Canadian Border (Amtrak)

    1. Take the train from Canadian Border to Ny Moynihan Train Hall At Penn Stationtrain train Maple Leaf
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    26h 20m
    $352–726

  6. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    29h 20m
    $267–669

Niagara Falls to Florence by train (Amtrak)

Calendar14Weekly Trains
Duration24h 34mAverage Duration
Ticket$352Cheapest Price
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Questions & Answers

Map of how to get from Niagara Falls to Florence.ExpandLaunch map view
  • Distance: 639.9 mi
  • Duration: 5h 54m

What companies run services between Niagara Falls, NY, USA and Florence, SC, USA?

You can take a bus from Niagara Falls USA to Florence, SC via New York Midtown, 23 St, East Broadway, and New York, NY in around 22h 49m. Alternatively, you can take a train from Niagara Falls Amtrak Station to Florence Station via Ny Moynihan Train Hall At Penn Station in around 24h 34m.

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