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How to get fromNiagara Falls to Great Smoky Mountainsby bus, plane, car, or train

Find Transport to Great Smoky Mountains

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There are 11 ways to get from Niagara Falls to Great Smoky Mountains by bus, plane, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport, drive

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 30m
    $185–974

  2. Bus to Buffalo Niagara International Airport, fly to Hartsfield-Jackson Atlanta International Airport, drive

    cheapest
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane BUF - ATL
    3. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    8h 5m
    $90–343

  3. Train, bus, drive

    1. Take the train from Niagara Falls Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    24h 19m
    $258–436

  4. Train, bus, drive via Greensboro

    1. Take the train from Niagara Falls Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    26h 36m
    $347–715

  5. Drive 743.1 mi

    1. Drive from Niagara Falls to Great Smoky Mountainscar car 743.1 mi
    13h 19m
    $136–196

  6. Bus to Buffalo Niagara International Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Asheville Regional Airport (AVL)plane plane BUF - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    8h
    $114–530

  7. Train to Toronto Island Airport, fly to Mcghee Tyson Airport, drive

    1. Take the train from Canadian Border to Torontotrain train
    2. Fly from Toronto Island Airport (YTZ) to Mcghee Tyson Airport (TYS)plane plane YTZ - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    10h 50m
    $166–770

  8. Train to Toronto Pearson International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the train from Niagara Falls to Toronto Union Stationtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS)plane plane YYZ - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    10h 32m
    $142–778

  9. Bus, drive via Ellicott Street & MTC Static

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus
    2. Take the bus from New York to Knoxvillebus bus Nyc
    3. Drive from Knoxville to Great Smoky Mountainscar car
    25h 28m
    $168–415

  10. Bus, drive

    1. Take the bus from Niagara Falls USA to New York Midtownbus bus
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    25h 39m
    $185–256

  11. Train, bus, drive via Niagara Falls

    1. Take the train from Niagara Falls to New York Penn Stationtrain train
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    26h 12m
    $237–425

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar90Weekly Planes
Duration4h 50mAverage Duration
Ticket$178Cheapest Price
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Questions & Answers

Map of how to get from Niagara Falls to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 657.1 mi
  • Duration: 7h 30m

What companies run services between Niagara Falls, NY, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Niagara Falls to Great Smoky Mountains. However, you can take the bus to Buffalo Niagara International Airport, walk to Buffalo Niagara International Airport (BUF) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a train from Niagara Falls Amtrak Station to Great Smoky Mountains via Ny Moynihan Train Hall At Penn Station, 34 St-Herald Sq, East Broadway, New York, NY, and Knoxville, TN in around 24h 19m.

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