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How to get fromNiagara Falls to Iowaby bus, plane, bus (Greyhound), train, car, or bus (Flixbus, Amtrak, Greyhound)

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There are 9 ways to get from Niagara Falls to Iowa by bus, plane, bus (Greyhound), train, car, or bus (Flixbus, Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Des Moines

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    5h 56m
    $151–728

  2. Bus, fly to Quad City International Airport

    cheapest
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Quad City International Airport (MLI)plane plane BUF - MLI
    7h 36m
    $81–429

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    21h 17m
    $128–253

  4. Train, bus via Galesburg

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    21h 55m
    $226–619

  5. Drive  835.3 mi

    1. Drive from Niagara Falls to Des Moinescar car 835.3 mi
    13h 56m
    $153–221

  6. Bus, fly to Omaha

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Omaha (OMA)plane plane BUF - OMA
    6h 5m
    $149–637

  7. Bus, fly to The Eastern Iowa Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to The Eastern Iowa Airport (CID)plane plane BUF - CID
    6h 31m
    $124–487

  8. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    22h 46m
    $199–417

  9. Bus via Dearborn

    1. Take the bus from Niagara Falls, ON to Toronto Union Stationbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Dearborn to Chicago Union Stationbus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    24h 58m
    $172–332

Buffalo Niagara International Airport (BUF) to Des Moines (DSM) flights

Calendar106Weekly Planes
Duration5h 26mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Niagara Falls to Iowa.ExpandLaunch map view
  • Distance: 806 mi
  • Duration: 5h 56m

What companies run services between Niagara Falls, NY, USA and Iowa, USA?

You can take a bus from Pine Avenue & Main Street to Des Moines via Ellicott Street & MTC Static, Buffalo, Cleveland Bus Station, Chicago Bus Station, and Des Moines in around 21h 17m.

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Bus operators

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