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How to get fromNiagara Falls to Knoxvilleby bus, plane, train, car, or bus (Flixbus)

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There are 10 ways to get from Niagara Falls to Knoxville by bus, plane, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    5h 56m
    $250–1,078

  2. Drive 702.8 mi

    cheapest
    1. Drive from Niagara Falls to Knoxvillecar car 702.8 mi
    11h 55m
    $129–186

  3. Train, bus

    1. Take the train from Niagara Falls Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    22h 30m
    $290–467

  4. Train to Rochester, fly to Mcghee Tyson Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Mcghee Tyson Airport (TYS)plane plane ROC - TYS
    6h 57m
    $280–1,208

  5. Bus to Buffalo Niagara International Airport, fly to Nashville, drive

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Nashville (BNA)plane plane BUF - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 34m
    $135–658

  6. Train to Toronto Island Airport, fly to Mcghee Tyson Airport

    1. Take the train from Canadian Border to Torontotrain train
    2. Fly from Toronto Island Airport (YTZ) to Mcghee Tyson Airport (TYS)plane plane YTZ - TYS
    9h 15m
    $222–824

  7. Train to Toronto Pearson International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Niagara Falls to Toronto Union Stationtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS)plane plane YYZ - TYS
    8h 58m
    $187–831

  8. Bus

    1. Take the bus from Niagara Falls USA to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    22h 41m
    $261–380

  9. Bus via Buffalo

    1. Take the bus from Buffalo to New Yorkbus bus Adt N813 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    23h 37m
    $245–535

  10. Train, bus via Farragut

    1. Take the train from Niagara Falls to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    24h 19m
    $309–546

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar91Weekly Planes
Duration4h 50mAverage Duration
Ticket$189Cheapest Price
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Questions & Answers

Map of how to get from Niagara Falls to Knoxville.ExpandLaunch map view
  • Distance: 610.7 mi
  • Duration: 5h 56m

What companies run services between Niagara Falls, NY, USA and Knoxville, TN, USA?

You can take a bus from Niagara Falls USA to Knoxville via New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 22h 41m.

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