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How to get fromNiagara Falls to Knoxvilleby bus, plane, train, car, bus (Flixbus), or bus (Greyhound)

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There are 9 ways to get from Niagara Falls to Knoxville by bus, plane, train, car, bus (Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    6h 7m
    $250–1,177

  2. Bus to Buffalo Niagara International Airport, fly to Nashville, drive

    cheapest
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Nashville (BNA)plane plane BUF - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 44m
    $115–527

  3. Train, bus

    1. Take the train from Niagara Falls Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    22h 30m
    $394–555

  4. Drive  702.8 mi

    1. Drive from Niagara Falls to Knoxvillecar car 702.8 mi
    11h 55m
    $129–186

  5. Bus to Toronto Island Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Island Airport (YTZ) to Mcghee Tyson Airport (TYS)plane plane YTZ - TYS
    8h 55m
    $242–1,126

  6. Bus to Toronto Pearson International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS)plane plane YYZ - TYS
    9h 19m
    $212–1,026

  7. Bus

    1. Take the bus from Niagara Falls USA to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    22h 41m
    $253–356

  8. Bus via Ellicott Street & MTC Static

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus Greyhound US0205 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    23h 44m
    $240–505

  9. Train, bus via Farragut

    1. Take the train from Niagara Falls to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    24h 25m
    $304–544

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar67Weekly Planes
Duration4h 41mAverage Duration
Ticket$190Cheapest Price
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Comparing Your Travel Options

Map of how to get from Niagara Falls to Knoxville.ExpandLaunch map view
  • Distance: 610.7 mi
  • Duration: 6h 7m

What companies run services between Niagara Falls, NY, USA and Knoxville, TN, USA?

You can take a bus from Niagara Falls USA to Knoxville via New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 22h 41m.

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