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How to get fromNiagara Falls to Louisvilleby bus, plane, train, bus (Flixbus, Greyhound, Amtrak), car, or bus (Greyhound, Amtrak)

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There are 10 ways to get from Niagara Falls to Louisville by bus, plane, train, bus (Flixbus, Greyhound, Amtrak), car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Louisville International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    6h 50m
    $116–710

  2. Bus to Buffalo Niagara International Airport, fly to Blue Grass Airport, drive

    cheapest
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Blue Grass Airport (LEX)plane plane BUF - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 47m
    $83–416

  3. Train, bus

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Toledotrain train
    3. Take the bus from Toledo to Indianapolisbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    15h 20m
    $212–501

  4. Bus via Columbus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    17h 6m
    $100–175

  5. Drive  550.9 mi

    1. Drive from Niagara Falls to Louisvillecar car 550.9 mi
    9h 26m
    $101–146

  6. Train to Rochester, fly to Louisville International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Louisville International Airport (SDF)plane plane ROC - SDF
    7h 51m
    $205–1,137

  7. Bus to Toronto Pearson International Airport, fly to Louisville International Airport

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Louisville International Airport (SDF)plane plane YYZ - SDF
    9h 52m
    $98–609

  8. Bus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    17h 7m
    $88–177

  9. Train, bus via Ellicott Street & MTC Static

    1. Take the train from Buffalo Depew Station to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    18h 17m
    $223–361

  10. Train, bus #2

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    21h 8m
    $411–806

Niagara Falls to Louisville by train and bus

Calendar7Weekly Services
Duration15h 20mAverage Duration
Ticket$212Cheapest Price
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Comparing Your Travel Options

Map of how to get from Niagara Falls to Louisville.ExpandLaunch map view
  • Distance: 530.1 mi
  • Duration: 6h 50m

What companies run services between Niagara Falls, NY, USA and Louisville, KY, USA?

You can take a bus from Pine Avenue & Main Street to Louisville, KY via Ellicott Street & MTC Static, Buffalo, Columbus, S 3Rd St & E Town St, E Livingston Ave & Macon Aly, Columbus, and Indianapolis Union Station in around 17h 6m.

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