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How to get fromNiagara Falls to Louisvilleby bus, plane, train, car, bus (Flixbus, Greyhound), or bus (Greyhound)

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There are 9 ways to get from Niagara Falls to Louisville by bus, plane, train, car, bus (Flixbus, Greyhound), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Louisville International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    6h 40m
    $116–660

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Akronbus bus Bsb 11
    2. Take the bus from Akron to Louisvillebus bus Bsb 27
    14h 2m
    $59–152

  3. Train, bus

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Toledotrain train
    3. Take the bus from Toledo Bus Stop to Louisville Bus Stationbus bus
    14h 10m
    $129–386

  4. Drive  550.9 mi

    1. Drive from Niagara Falls to Louisvillecar car 550.9 mi
    9h 26m
    $101–146

  5. Bus to Buffalo Niagara International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Blue Grass Airport (LEX)plane plane BUF - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 44m
    $83–426

  6. Train to Rochester, fly to Louisville International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Louisville International Airport (SDF)plane plane ROC - SDF
    7h 46m
    $195–1,037

  7. Bus to Toronto Pearson International Airport, fly to Louisville International Airport

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Louisville International Airport (SDF)plane plane YYZ - SDF
    9h 42m
    $98–606

  8. Bus via Columbus

    1. Take the bus from Buffalo to Columbusbus bus FlixBus 2526
    2. Take the bus from Columbus to Louisvillebus bus Bsb 27 / ...
    14h 16m
    $79–135

  9. Bus #2

    1. Take the bus from Buffalo, NY to Cincinnati, OHbus bus Buffalo / ...
    2. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus Cleveland / ...
    14h 47m
    $64–124

Niagara Falls to Louisville by bus

Calendar7Weekly Buses
Duration14h 2mAverage Duration
Ticket$59Cheapest Price
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Comparing Your Travel Options

Map of how to get from Niagara Falls to Louisville.ExpandLaunch map view
  • Distance: 530.1 mi
  • Duration: 6h 40m

What companies run services between Niagara Falls, NY, USA and Louisville, KY, USA?

You can take a bus from Pine Avenue & Main Street to Louisville via Buffalo and Akron in around 14h 2m.

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