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How to get fromNiagara Falls to Panama City Beachby bus, plane, bus (Greyhound), train, or car

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There are 10 ways to get from Niagara Falls to Panama City Beach by bus, plane, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Northwest Florida Beaches International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Northwest Florida Beaches International Airport (ECP)plane plane BUF - ECP
    6h 27m
    $175–673

  2. Bus to Buffalo Niagara International Airport, fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Destin–Fort Walton Beach Airport (VPS)plane plane BUF - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    7h 47m
    $135–624

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    33h 21m
    $206–404

  4. Train, bus via Chicago

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to New Orleans Union Passenger Terminaltrain train
    4. Take the bus from New Orleans Bus Station to Mobile Bus Stationbus bus
    5. Take the bus from Mobile Bus Station to Panama City Beach Bus Stationbus bus
    41h 5m
    $533–1,251

  5. Drive 1,179.3 mi

    1. Drive from Niagara Falls to Panama City Beachcar car 1,179.3 mi
    20h 30m
    $216–311

  6. Train to Rochester, fly to Northwest Florida Beaches International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Northwest Florida Beaches International Airport (ECP)plane plane ROC - ECP
    7h 44m
    $215–853

  7. Bus to Buffalo Niagara International Airport, fly to Dothan Regional Airport, drive

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Dothan Regional Airport (DHN)plane plane BUF - DHN
    3. Drive from Dothan Regional Airport (DHN) to Panama City Beachcar car
    9h 8m
    $182–584

  8. Train to Toronto Pearson International Airport, fly to Northwest Florida Beaches International Airport

    1. Take the train from Niagara Falls to Toronto Union Stationtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Northwest Florida Beaches International Airport (ECP)plane plane YYZ - ECP
    9h 28m
    $152–626

  9. Train, bus

    1. Take the train from Niagara Falls Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Orlandotrain train
    3. Take the bus from Orlando to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    42h 26m
    $594–1,197

  10. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Panama City Beach Bus Stationbus bus
    44h 38m
    $442–1,067

Buffalo Niagara International Airport (BUF) to Northwest Florida Beaches International Airport (ECP) flights

Calendar61Weekly Planes
Duration5h 57mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

Map of how to get from Niagara Falls to Panama City Beach.ExpandLaunch map view
  • Distance: 1,002.5 mi
  • Duration: 6h 27m

What companies run services between Niagara Falls, NY, USA and Panama City Beach, FL, USA?

You can take a bus from Pine Avenue & Main Street to Panama City Beach via Ellicott Street & MTC Static, Buffalo, Cleveland Bus Station, Nashville Bus Station, Tallahassee, and Panama City Beach Bus Station in around 33h 21m.

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