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How to get fromNiagara Falls to Senecaby bus, plane, taxi, train, car, or train (Amtrak)

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There are 9 ways to get from Niagara Falls to Seneca by bus, plane, taxi, train, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Greenville–Spartanburg International Airport, taxi

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Greenville–Spartanburg International Airport (GSP)plane plane BUF - GSP
    3. Take the taxi from Greenville–Spartanburg International Airport (GSP) to Senecataxi taxi
    6h 47m
    $245–877

  2. Bus, fly to Asheville Regional Airport, drive

    cheapest
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Asheville Regional Airport (AVL)plane plane BUF - AVL
    3. Drive from Asheville-Airport-AVL to Senecacar car
    7h 43m
    $87–436

  3. Bus, taxi

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    4. Take the taxi from Taqueria Guadalajara - Greenville to Senecataxi taxi
    25h 18m
    $265–412

  4. Bus, train

    1. Take the bus from Niagara Falls USA to Newark Penn Stationbus bus FlixBus N2686 / ...
    2. Take the train from Newark Penn Station to Clemson Amtrak Stationtrain train Crescent
    25h 29m
    $491–779

  5. Drive  773.5 mi

    1. Drive from Niagara Falls to Senecacar car 773.5 mi
    14h 14m
    $142–204

  6. Bus, fly to Hartsfield-Jackson Atlanta International Airport, taxi

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane BUF - ATL
    3. Take the bus from Atlanta to Flying J - Commercebus bus
    4. Take the taxi from Flying J - Commerce to Senecataxi taxi
    8h 43m
    $175–450

  7. Bus, fly to Charlotte Douglas International Airport, train

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT)plane plane BUF - CLT
    3. Take the train from Charlotte Amtrak Station to Clemson Amtrak Stationtrain train
    9h 26m
    $208–813

  8. Train (Amtrak)

    1. Take the train from Niagara Falls Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Clemson Amtrak Stationtrain train Crescent
    26h 12m
    $680–1,072

  9. Train via Canadian Border (Amtrak)

    1. Take the train from Canadian Border to Ny Moynihan Train Hall At Penn Stationtrain train Maple Leaf
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Clemson Amtrak Stationtrain train Crescent
    27h 58m
    $680–1,072

Buffalo Niagara International Airport (BUF) to Greenville–Spartanburg International Airport (GSP) flights

Calendar81Weekly Planes
Duration4h 37mAverage Duration
Ticket$118Cheapest Price
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Comparing Your Travel Options

Map of how to get from Niagara Falls to Seneca.ExpandLaunch map view
  • Distance: 667 mi
  • Duration: 6h 47m

What companies run services between Niagara Falls, NY, USA and Seneca, SC, USA?

You can take a train from Niagara Falls Amtrak Station to Seneca via Ny Moynihan Train Hall At Penn Station and Clemson Amtrak Station in around 26h 12m.

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