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How to get fromNiagara Falls to St. Louisby bus, plane, train (Amtrak), bus (Greyhound), car, or train

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There are 7 ways to get from Niagara Falls to St. Louis by bus, plane, train (Amtrak), bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 18m
    $108–610

  2. Bus to Toronto Pearson International Airport, fly

    cheapest
    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    7h 25m
    $95–516

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    18h 5m
    $209–621

  4. Bus

    1. Take the bus from Buffalo to Columbusbus bus Bsb 11 / ...
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    19h 7m
    $102–192

  5. Drive  753.5 mi

    1. Drive from Niagara Falls to St. Louiscar car 753.5 mi
    13h
    $138–199

  6. Train to Rochester, fly

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    7h 23m
    $187–938

  7. Bus via Pittsburgh

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    23h 27m
    $147–372

Niagara Falls to St. Louis by train

Calendar14Weekly Trains
Duration18h 5mAverage Duration
Ticket$209Cheapest Price
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Comparing Your Travel Options

Map of how to get from Niagara Falls to St. Louis.ExpandLaunch map view
  • Distance: 718 mi
  • Duration: 6h 18m

What companies run services between Niagara Falls, NY, USA and St. Louis, MO, USA?

You can take a train from Niagara Falls Amtrak Station to St. Louis via Buffalo Depew Station and Chicago Union Station in around 18h 5m. Alternatively, you can take a bus from Pine Avenue & Main Street to St Louis Bus Station via Buffalo and Columbus in around 19h 7m.

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