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How to get fromNiagara-on-the-Lake to Chicagoby bus, plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus (Flixbus, Amtrak)

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There are 10 ways to get from Niagara-on-the-Lake to Chicago by bus, plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    5h 47m
    $107–444

  2. Bus

    cheapest
    1. Take the bus from Niagara-on-the-Lake to Torontobus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus
    16h 35m
    $93–177

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    12h 46m
    $183–505

  4. Drive 517.9 mi

    1. Drive from Niagara-on-the-Lake to Chicagocar car 517.9 mi
    8h 46m
    $119–172

  5. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    6h 10m
    $157–384

  6. Bus to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara-on-the-Lake to Torontobus bus
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    6h 38m
    $185–1,327

  7. Bus to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara-on-the-Lake to Torontobus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    6h 57m
    $345–1,127

  8. Bus to Toronto Island Airport, fly to Chicago Midway International Airport

    1. Take the bus from Niagara-on-the-Lake to Torontobus bus
    2. Fly from Toronto Island Airport (YTZ) to Chicago Midway International Airport (MDW)plane plane YTZ - MDW
    6h 29m
    $155–457

  9. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    7h 45m
    $128–640

  10. Bus via Detroit

    1. Take the bus from Niagara-on-the-Lake to Torontobus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit to Chicago Union Stationbus bus
    16h 47m
    $148–232

Niagara-on-the-Lake to Chicago by bus

Calendar12Weekly Buses
Duration16h 35mAverage Duration
Ticket$93Cheapest Price
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Questions & Answers

Map of how to get from Niagara-on-the-Lake to Chicago.ExpandLaunch map view
  • Distance: 530.8 mi
  • Duration: 5h 47m

What companies run services between Niagara-on-the-Lake, ON, Canada and Chicago, IL, USA?

You can take a vehicle from Niagara-on-the-Lake to Chicago Union Station via Niagara Falls Amtrak Station and Buffalo Depew Station in around 12h 46m. Alternatively, you can take a bus from Niagara-on-the-Lake to Chicago Bus Station via Toronto and Detroit Bus Station in around 16h 35m.

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