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How to get fromNiagara-on-the-Lake to Des Moinesby bus, plane, train, bus (Flixbus, Greyhound), or car

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There are 8 ways to get from Niagara-on-the-Lake to Des Moines by bus, plane, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    7h 36m
    $202–930

  2. Bus to Toronto Pearson International Airport, fly

    cheapest
    1. Take the bus from Niagara-on-the-Lake to Torontobus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Des Moines (DSM)plane plane YYZ - DSM
    8h 44m
    $140–642

  3. Train, bus via Galesburg

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    22h 17m
    $263–675

  4. Bus

    1. Take the bus from Niagara-on-the-Lake to Torontobus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit, MI to Indianapolis, INbus bus
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    26h 45m
    $150–301

  5. Drive 832.7 mi

    1. Drive from Niagara-on-the-Lake to Des Moinescar car 832.7 mi
    13h 58m
    $191–276

  6. Bus to Toronto Island Airport, fly

    1. Take the bus from Niagara-on-the-Lake to Torontobus bus
    2. Fly from Toronto Island Airport (YTZ) to Des Moines (DSM)plane plane YTZ - DSM
    8h 9m
    $150–692

  7. Train to Rochester, fly

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Des Moines (DSM)plane plane ROC - DSM
    9h 35m
    $243–1,166

  8. Train, bus

    1. Take the train from Niagara Falls to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    23h 36m
    $234–605

Niagara-on-the-Lake to Des Moines by bus

Calendar6Weekly Buses
Duration26h 45mAverage Duration
Ticket$150Cheapest Price
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Questions & Answers

Map of how to get from Niagara-on-the-Lake to Des Moines.ExpandLaunch map view
  • Distance: 828 mi
  • Duration: 7h 36m

What companies run services between Niagara-on-the-Lake, ON, Canada and Des Moines, IA, USA?

You can take a bus from Niagara-on-the-Lake to Des Moines via Toronto, Detroit, MI, and Indianapolis Union Station in around 26h 45m.

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Train operators
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