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How to get fromNiles to Mayo Clinicby plane, train, bus, car, or bus (Greyhound)

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There are 8 ways to get from Niles to Mayo Clinic by plane, train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Rochester

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 12m
    $45–337

  2. Train, bus

    1. Take the train from Glenview Amtrak Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    9h 9m
    $93–147

  3. Train, bus via Saint Paul

    1. Take the train from Glenview Amtrak Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    10h 53m
    $150–302

  4. Drive 334.3 mi

    1. Drive from Niles to Mayo Cliniccar car 334.3 mi
    5h 33m
    $61–89

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 55m
    $276–509

  6. Fly Chicago Midway International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 46m
    $133–544

  7. Bus

    1. Take the bus from Chicago to Milwaukee Intermodal Stationbus bus Greyhound US0150 / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    9h 26m
    $83–125

  8. Bus via Madison

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    9h 45m
    $76–128

Niles to Mayo Clinic by bus, train, and foot

Calendar7Weekly Services
Duration9h 9mAverage Duration
Ticket$93Cheapest Price
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Questions & Answers

Map of how to get from Niles to Mayo Clinic.ExpandLaunch map view
  • Distance: 289.3 mi
  • Duration: 4h 12m

What companies run services between Niles, IL, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Touhy Ave & Milwaukee Ave to Mayo Clinic via Cumberland CTA Station, Chicago, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 9h 26m.

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