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How to get fromNorth Carolina to Buffaloby plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

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There are 8 ways to get from North Carolina to Buffalo by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charlotte Douglas International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Buffalo Niagara International Airport (BUF)plane plane CLT - BUF
    4h 27m
    $102–580

  2. Bus via Charleston

    cheapest
    1. Take the bus from Charlotte Bus Station to Charleston, WVbus bus
    2. Take the bus from Charleston, WV to Cleveland, OHbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    16h 40m
    $91–202

  3. Train (Amtrak)

    1. Take the train from Charlotte Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Crescent / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    23h 53m
    $262–662

  4. Drive  653.8 mi

    1. Drive from Charlotte to Buffalocar car 653.8 mi
    11h 11m
    $120–173

  5. Fly Raleigh-Durham International Airport to Buffalo Niagara International Airport

    1. Fly from Raleigh-Durham International Airport (RDU) to Buffalo Niagara International Airport (BUF)plane plane RDU - BUF
    4h 31m
    $128–440

  6. Fly Charlotte Douglas International Airport to Rochester, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Rochester (ROC)plane plane CLT - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 59m
    $161–843

  7. Fly Concord to Rochester, bus

    1. Fly from Concord (USA) to Rochester (ROC)plane plane USA - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 54m
    $391–1,283

  8. Bus

    1. Take the bus from Charlotte to Columbusbus bus Bsb 33
    2. Take the bus from Columbus to Buffalobus bus FlixBus 2526
    20h 7m
    $101–183

North Carolina to Buffalo by bus

Calendar14Weekly Buses
Duration16h 40mAverage Duration
Ticket$91Cheapest Price
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Comparing Your Travel Options

Map of how to get from North Carolina to Buffalo.ExpandLaunch map view
  • Distance: 563.3 mi
  • Duration: 4h 27m

What companies run services between North Carolina, USA and Buffalo, NY, USA?

American Airlines, Southwest Airlines, and United Airlines fly from Charlotte Douglas International Airport (CLT) to Buffalo Niagara International Airport (BUF) every 3 hours. Alternatively, you can take a bus from Charlotte Bus Station to Buffalo, NY via Charleston, WV and Cleveland, OH in around 16h 40m.

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Need to know: Greyhound

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