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How to get fromNorth Carolina to Des Moinesby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 10 ways to get from North Carolina to Des Moines by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charlotte Douglas International Airport

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    3h 59m
    $189–873

  2. Fly from Wilmington International Airport

    cheapest
    1. Fly from Wilmington International Airport (ILM) to Des Moines (DSM)plane plane ILM - DSM
    5h 2m
    $181–788

  3. Bus

    1. Take the bus from Charlotte to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    25h 35m

  4. Train, bus

    1. Take the train from Charlotte Amtrak Station to Charlottesvilletrain train
    2. Take the train from Charlottesville to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    33h 48m
    $347–722

  5. Drive 1,030 mi

    1. Drive from Charlotte to Des Moinescar car 1,030 mi
    17h 42m
    $188–272

  6. Fly from Piedmont Triad International Airport

    1. Fly from Piedmont Triad International Airport (GSO) to Des Moines (DSM)plane plane GSO - DSM
    4h 51m
    $238–1,007

  7. Fly from Raleigh-Durham International Airport

    1. Fly from Raleigh-Durham International Airport (RDU) to Des Moines (DSM)plane plane RDU - DSM
    5h 44m
    $190–824

  8. Bus via Columbus

    1. Take the bus from Charlotte to Columbusbus bus
    2. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Chicagobus bus
    3. Take the bus from Chicago to Des Moinesbus bus
    27h 30m

  9. Train, bus via Chicago

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the bus from Chicago to Des Moinesbus bus
    38h 41m

  10. Train, bus via Galesburg

    1. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    39h 27m
    $487–1,042

Charlotte Douglas International Airport (CLT) to Des Moines (DSM) flights

Calendar82Weekly Planes
Duration4h 8mAverage Duration
Ticket$173Cheapest Price
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Questions & Answers

Map of how to get from North Carolina to Des Moines.ExpandLaunch map view
  • Distance: 827.6 mi
  • Duration: 3h 59m

What companies run services between North Carolina, USA and Des Moines, IA, USA?

American Airlines, Southwest Airlines, and two other airlines fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM) every 2 hours. Alternatively, you can take a bus from Charlotte to Des Moines via Atlanta Bus Station and St Louis Bus Station in around 25h 35m.

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