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How to get fromNorth Carolina to Florida Keysby plane, bus, shuttle, train, car, or bus (Greyhound, Flixbus)

Find Transport to Florida Keys

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There are 12 ways to get from North Carolina to Florida Keys by plane, bus, shuttle, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charlotte Douglas International Airport to Key West International Airport

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    6h 39m
    $144–446

  2. Bus, shuttle

    1. Take the bus from Charlotte Bus Station to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Fort Lauderdale International Airportbus bus
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    21h 27m
    $281–372

  3. Bus, train

    1. Take the bus from Charlotte Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h 15m
    $293–697

  4. Drive  867.4 mi

    1. Drive from Charlotte to Florida Keyscar car 867.4 mi
    15h 3m
    $159–229

  5. Fly Raleigh-Durham International Airport to Key West International Airport

    1. Fly from Raleigh-Durham International Airport (RDU) to Key West International Airport (EYW)plane plane RDU - EYW
    6h 59m
    $150–476

  6. Fly Wilmington International Airport to Miami International Airport, shuttle

    1. Fly from Wilmington International Airport (ILM) to Miami International Airport (MIA)plane plane ILM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 38m
    $231–571

  7. Fly Charlotte Douglas International Airport to Miami International Airport, shuttle

    1. Fly from Charlotte Douglas International Airport (CLT) to Miami International Airport (MIA)plane plane CLT - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 57m
    $284–566

  8. Fly Raleigh-Durham International Airport to Miami International Airport, shuttle

    1. Fly from Raleigh-Durham International Airport (RDU) to Miami International Airport (MIA)plane plane RDU - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 7m
    $254–886

  9. Fly Charlotte Douglas International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Charlotte Douglas International Airport (CLT) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CLT - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 26m
    $254–556

  10. Fly Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Raleigh-Durham International Airport (RDU) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane RDU - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 33m
    $304–656

  11. Bus

    1. Take the bus from Charlotte Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    25h 50m
    $154–253

  12. Train, bus

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    33h 25m
    $348–885

North Carolina to Florida Keys by bus, foot, and shuttle

Calendar7Weekly Services
Duration21h 27mAverage Duration
Ticket$281Cheapest Price
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Comparing Your Travel Options

Map of how to get from North Carolina to Florida Keys.ExpandLaunch map view
  • Distance: 767.6 mi
  • Duration: 6h 39m

What companies run services between North Carolina, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW) every 3 hours. Alternatively, you can take a bus from Charlotte Bus Station to Florida Keys via Fayetteville Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 25h 50m.

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