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How to get fromNorth Carolina to Florida Keysby plane, bus, shuttle, train, car, or bus (Flixbus, Greyhound)

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There are 11 ways to get from North Carolina to Florida Keys by plane, bus, shuttle, train, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charlotte Douglas International Airport to Key West International Airport

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    6h 29m
    $159–506

  2. Bus

    cheapest
    1. Take the bus from Charlotte Bus Station to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    21h 43m
    $142–252

  3. Bus, shuttle

    1. Take the bus from Charlotte Bus Station to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Fort Lauderdale International Airportbus bus
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    21h 27m
    $287–402

  4. Bus, train

    1. Take the bus from Charlotte Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h 15m
    $332–658

  5. Drive 867.4 mi

    1. Drive from Charlotte to Florida Keyscar car 867.4 mi
    15h 2m
    $159–229

  6. Fly Raleigh-Durham International Airport to Key West International Airport

    1. Fly from Raleigh-Durham International Airport (RDU) to Key West International Airport (EYW)plane plane RDU - EYW
    6h 50m
    $200–346

  7. Fly Wilmington International Airport to Miami International Airport, shuttle

    1. Fly from Wilmington International Airport (ILM) to Miami International Airport (MIA)plane plane ILM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 34m
    $231–551

  8. Fly Charlotte Douglas International Airport to Miami International Airport, shuttle

    1. Fly from Charlotte Douglas International Airport (CLT) to Miami International Airport (MIA)plane plane CLT - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 59m
    $284–566

  9. Fly Raleigh-Durham International Airport to Miami International Airport, shuttle

    1. Fly from Raleigh-Durham International Airport (RDU) to Miami International Airport (MIA)plane plane RDU - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 10m
    $274–886

  10. Fly Charlotte Douglas International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Charlotte Douglas International Airport (CLT) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CLT - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 24m
    $249–536

  11. Train, bus

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    33h 25m
    $403–830

North Carolina to Florida Keys by bus, foot, and shuttle

Calendar7Weekly Services
Duration21h 27mAverage Duration
Ticket$287Cheapest Price
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Questions & Answers

Map of how to get from North Carolina to Florida Keys.ExpandLaunch map view
  • Distance: 767.6 mi
  • Duration: 6h 29m

What companies run services between North Carolina, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Charlotte Bus Station to Florida Keys via Orlando Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 21h 43m.

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