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How to get fromNorth Carolina to Mayo Clinicby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 12 ways to get from North Carolina to Mayo Clinic by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charlotte Douglas International Airport to Rochester

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Rochester (RST)plane plane CLT - RST
    8h 1m
    $103–592

  2. Bus, train

    1. Take the bus from Charlotte Bus Station to Toledo Bus Stopbus bus
    2. Take the train from Toledo to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee to Rochesterbus bus
    28h 20m
    $259–493

  3. Train, bus via Madison

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    40h 28m
    $467–992

  4. Drive 1,088.1 mi

    1. Drive from Charlotte to Mayo Cliniccar car 1,088.1 mi
    18h 37m
    $199–287

  5. Fly Wilmington International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Wilmington International Airport (ILM) to Minneapolis–Saint Paul International Airport (MSP)plane plane ILM - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 3m
    $186–669

  6. Fly Raleigh-Durham International Airport to Rochester

    1. Fly from Raleigh-Durham International Airport (RDU) to Rochester (RST)plane plane RDU - RST
    7h 18m
    $104–522

  7. Fly Charlotte Douglas International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLT - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 58m
    $194–754

  8. Fly Raleigh-Durham International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Raleigh-Durham International Airport (RDU) to Minneapolis–Saint Paul International Airport (MSP)plane plane RDU - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 10m
    $174–904

  9. Fly Charlotte Douglas International Airport to Dane County Regional Airport-Truax Field, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Dane County Regional Airport-Truax Field (MSN)plane plane CLT - MSN
    2. Take the bus from Madison to Rochesterbus bus
    10h 3m
    $194–829

  10. Bus via Columbus

    1. Take the bus from Charlotte Bus Station to Hurricanebus bus
    2. Take the bus from Hurricane to Columbus - Mound Stbus bus
    3. Take the bus from Columbus - Mound St to Chicagobus bus
    4. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    5. Take the bus from Madison to Rochesterbus bus
    30h 23m
    $151–339

  11. Bus

    1. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    31h 3m
    $220–406

  12. Train, bus

    1. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    41h
    $555–1,182

North Carolina to Mayo Clinic by bus, train, and foot

Calendar7Weekly Services
Duration28h 20mAverage Duration
Ticket$259Cheapest Price
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Questions & Answers

Map of how to get from North Carolina to Mayo Clinic.ExpandLaunch map view
  • Distance: 875 mi
  • Duration: 8h 1m

What companies run services between North Carolina, USA and Mayo Clinic, MN, USA?

American Airlines, Delta, and United Airlines fly from Charlotte Douglas International Airport (CLT) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Charlotte Bus Station to Mayo Clinic via Hurricane, Columbus - Mound St, Chicago, W Jackson Blvd, after S Clinton St, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 30h 23m.

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