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How to get fromNorth Carolina to St. Louisby plane, bus (Flixbus, Greyhound), car, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 8 ways to get from North Carolina to St. Louis by plane, bus (Flixbus, Greyhound), car, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charlotte Douglas International Airport

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    4h 5m
    $125–655

  2. Bus via Columbus

    cheapest
    1. Take the bus from Charlotte Bus Station to Columbusbus bus Greyhound US0140
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    20h 10m
    $111–226

  3. Bus

    1. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    15h 50m
    $124–243

  4. Drive 709 mi

    1. Drive from Charlotte to St. Louiscar car 709 mi
    12h 6m
    $130–187

  5. Fly from Piedmont Triad International Airport

    1. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    4h 54m
    $174–789

  6. Fly from Wilmington International Airport

    1. Fly from Wilmington International Airport (ILM) to Lambert–St. Louis International Airport (STL)plane plane ILM - STL
    5h 10m
    $127–620

  7. Fly from Raleigh-Durham International Airport

    1. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    4h 16m
    $556–1,006

  8. Bus via Charlotte

    1. Take the bus from Charlotte to Atlanta Bus Stationbus bus FlixBus N2470
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    16h 5m

North Carolina to St. Louis by bus

Calendar19Weekly Buses
Duration15h 50mAverage Duration
Ticket$124Cheapest Price
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Questions & Answers

Map of how to get from North Carolina to St. Louis.ExpandLaunch map view
  • Distance: 595.4 mi
  • Duration: 4h 5m

What companies run services between North Carolina, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and Delta fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Charlotte Bus Station to St Louis Bus Station via Atlanta Bus Station in around 15h 50m.

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