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How to get fromNorth Charleston to Chicagoby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, bus, or bus (Greyhound)

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There are 9 ways to get from North Charleston to Chicago by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charleston International Airport to Chicago Midway International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    3h 55m
    $79–387

  2. Fly Charleston International Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Charleston International Airport (CHS) to Chicago O'Hare International Airport (ORD)plane plane CHS - ORD
    4h 24m
    $69–337

  3. Bus via Savannah

    1. Take the bus from Charleston Bus Station to Savannah Bus Stationbus bus
    2. Take the bus from Savannah to Atlantabus bus
    3. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    23h 1m
    $188–353

  4. Train via Petersburg (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train Silver Meteor / ...
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train Floridian
    28h 57m
    $409–839

  5. Drive 866.9 mi

    1. Drive from North Charleston to Chicagocar car 866.9 mi
    15h 50m
    $159–229

  6. Train to Savannah, fly to Chicago Midway International Airport

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    2. Fly from Savannah (SAV) to Chicago Midway International Airport (MDW)plane plane SAV - MDW
    5h 56m
    $175–671

  7. Bus to Myrtle Beach, fly to Chicago Midway International Airport

    1. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    6h 8m
    $94–389

  8. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to Chicago Train Stationbus bus Greyhound US0100
    28h 30m
    $236–372

  9. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train Silver Meteor / ...
    2. Take the train from Savannah Station to Chicago Union Stationtrain train Floridian
    34h 51m
    $493–1,016

North Charleston to Chicago by bus

Calendar7Weekly Buses
Duration23h 1mAverage Duration
Ticket$188Cheapest Price
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Questions & Answers

Map of how to get from North Charleston to Chicago.ExpandLaunch map view
  • Distance: 759.9 mi
  • Duration: 3h 55m

What companies run services between North Charleston, SC, USA and Chicago, IL, USA?

Southwest Airlines and Delta fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW) every 4 hours. Alternatively, you can take a bus from Charleston Bus Station to Chicago Bus Station via Savannah Bus Station, Savannah, and Atlanta Bus Station in around 23h 1m.

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