What is the cheapest way to get from North Charleston to Knoxville?

The cheapest way to get from North Charleston to Knoxville is to drive which costs $65 - $100 and takes 6h 14m.

What is the fastest way to get from North Charleston to Knoxville?

The fastest way to get from North Charleston to Knoxville is to fly which takes 4h 36m and costs $140 - $650.

How far is it from North Charleston to Knoxville?

The distance between North Charleston and Knoxville is 320 miles. The road distance is 368.2 miles.

How long does it take to get from North Charleston to Knoxville?

It takes approximately 4h 36m to get from North Charleston to Knoxville, including transfers.

Can I drive from North Charleston to Knoxville?

Yes, the driving distance between North Charleston to Knoxville is 368 miles. It takes approximately 6h 14m to drive from North Charleston to Knoxville.

Where can I stay near Knoxville?

There are 320+ hotels available in Knoxville.

North Charleston to Knoxville - 5 ways to travel via plane, bus, and shuttle

How to get fromNorth Charleston to Knoxville

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There are 5 ways to get from North Charleston to Knoxville by plane, bus, shuttle, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly to Mcghee Tyson Airport
best
1. Fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS)plane CHS - TYS
4h 36m
$147–622
Drive 366.1 mi
cheapest
1. Drive from North Charleston to Knoxvillecar 366.1 mi
6h 14m
$67–97
Bus, shuttle, drive
1. Take the bus from Charleston Bus Station to Charlotte Bus Stationbus
2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus
3. Take a shuttle bus from Boone to Black Bear Resortshuttle
4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle
5. Drive from Hot Springs to Knoxvillecar
16h 17m
$372–439
Fly to Nashville, drive
1. Fly from Charleston International Airport (CHS) to Nashville (BNA)plane CHS - BNA
2. Drive from Nashville-Airport-BNA to Knoxvillecar
5h 23m
$382–1,152
Bus, taxi, shuttle, drive
1. Take the bus from Charleston Bus Station to Charlotte Bus Stationbus
2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus
3. Take the taxi from ASU Peacock Hall Boone to Black Bear Resorttaxi
4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle
5. Drive from Hot Springs to Chilhowee at Holstoncar
16h 32m
$407–504

Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) flights

104Weekly Planes

4h 20mAverage Duration

$90Cheapest Price

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Questions & Answers

Map of how to get from North Charleston to Knoxville.

Launch map view

Distance: 318.3 mi
Duration: 4h 36m

What companies run services between North Charleston, SC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) hourly.

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Bus operators

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How to get fromNorth Charleston to Knoxvilleby plane, bus, shuttle, car, or taxi

There are 5 ways to get from North Charleston to Knoxville by plane, bus, shuttle, car, or taxi

Fly to Mcghee Tyson Airport

Drive 366.1 mi

Bus, shuttle, drive

Fly to Nashville, drive

Bus, taxi, shuttle, drive