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How to get fromNorth Charleston to St. Louisby plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, bus, train, or bus (Greyhound, Flixbus)

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There are 7 ways to get from North Charleston to St. Louis by plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, bus, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charleston International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL)plane plane CHS - STL
    3h 57m
    $115–655

  2. Bus via Carbondale

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    23h 56m
    $155–250

  3. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    34h 43m
    $852–1,350

  4. Drive  834.4 mi

    1. Drive from North Charleston to St. Louiscar car 834.4 mi
    14h 35m
    $153–220

  5. Bus to Myrtle Beach, fly

    1. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL)plane plane MYR - STL
    6h 24m
    $125–592

  6. Train to Savannah, fly

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    2. Fly from Savannah (SAV) to Lambert–St. Louis International Airport (STL)plane plane SAV - STL
    5h 57m
    $229–889

  7. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    24h 15m
    $156–268

North Charleston to St. Louis by bus

Calendar5Weekly Buses
Duration23h 56mAverage Duration
Ticket$155Cheapest Price
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Comparing Your Travel Options

Map of how to get from North Charleston to St. Louis.ExpandLaunch map view
  • Distance: 722.3 mi
  • Duration: 3h 57m

What companies run services between North Charleston, SC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Charleston Bus Station to St. Louis via Atlanta Bus Station and Carbondale in around 23h 56m.

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