Rome2Rio

How to get fromNorth Charleston to St. Louisby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, bus, or bus (Greyhound)

Find Transport to St. Louis

See all options

There are 8 ways to get from North Charleston to St. Louis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charleston International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL)plane plane CHS - STL
    3h 52m
    $115–605

  2. Bus via Savannah

    1. Take the bus from Charleston Bus Station to Savannah Bus Stationbus bus
    2. Take the bus from Savannah to Atlantabus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    19h 20m

  3. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    34h 43m
    $499–1,028

  4. Drive 834.4 mi

    1. Drive from North Charleston to St. Louiscar car 834.4 mi
    14h 35m
    $153–220

  5. Train to Savannah, fly

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    2. Fly from Savannah (SAV) to Lambert–St. Louis International Airport (STL)plane plane SAV - STL
    5h 47m
    $226–919

  6. Bus to Myrtle Beach, fly

    1. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL)plane plane MYR - STL
    6h 9m
    $130–596

  7. Bus

    1. Take the bus from North Charleston to Atlantabus bus Ses 974
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    22h 40m

  8. Bus via Evansville

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    25h
    $160–309

Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL) flights

Calendar46Weekly Planes
Duration3h 43mAverage Duration
Ticket$112Cheapest Price
See schedules

Questions & Answers

Map of how to get from North Charleston to St. Louis.ExpandLaunch map view
  • Distance: 722.3 mi
  • Duration: 3h 52m

What companies run services between North Charleston, SC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Charleston Bus Station to St Louis Bus Station via Savannah Bus Station, Savannah, and Atlanta Bus Station in around 19h 20m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers