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How to get fromNorth Chicago to St. Louisby train (Amtrak), bus (Flixbus), car, train, plane, or bus

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There are 6 ways to get from North Chicago to St. Louis by train (Amtrak), bus (Flixbus), car, train, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from North Chicago to Chicago OTCtrain train Up-N
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    7h 7m
    $83–189

  2. Bus

    cheapest
    1. Take the bus from Tornado Bus Co - Waukegan to Tornado Bus Co - Chicagobus bus Milwaukee
    2. Take the bus from Chicago to St Louis Bus Stationbus bus FlixBus N2521
    9h 21m
    $55–109

  3. Drive 323 mi

    1. Drive from North Chicago to St. Louiscar car 323 mi
    5h 28m
    $59–86

  4. Train to Chicago Midway International Airport, fly

    1. Take the train from North Chicago to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    5h 8m
    $80–514

  5. Train to Chicago O'Hare International Airport, fly

    1. Take the train from North Chicago to Clybourntrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 15m
    $281–715

  6. Bus to General Mitchell International Airport, fly

    1. Take the bus from Metro Train Station - 13th Avenue and 54th Street to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 32m
    $493–872

North Chicago to St. Louis by train and bus

Calendar38Weekly Services
Duration7h 7mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from North Chicago to St. Louis.ExpandLaunch map view
  • Distance: 314.9 mi
  • Duration: 7h 7m

What companies run services between North Chicago, IL, USA and St. Louis, MO, USA?

You can take a train from North Chicago to St. Louis via Chicago OTC, Madison & Canal, Clinton & Jackson, and Chicago Union Station in around 7h 7m. Alternatively, you can take a bus from Lewis Ave & Audrey Nixon Blvd to St Louis Bus Station via 2253 N Belvidere Rd, Tornado Bus Co - Waukegan, California & 35th Street, Sox-35th Red Line Station, Sox-35th, 95th, and Chicago in around 9h 21m.

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