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How to get fromNorth Myrtle Beach to Florida Keysby plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

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There are 6 ways to get from North Myrtle Beach to Florida Keys by plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Myrtle Beach to Key West International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    8h 19m
    $198–500

  2. Drive  835.2 mi

    cheapest
    1. Drive from North Myrtle Beach to Florida Keyscar car 835.2 mi
    15h 20m
    $153–221

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 27m
    $237–496

  4. Bus

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h
    $209–323

  5. Fly Myrtle Beach to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 26m
    $368–680

  6. Bus to Wilmington International Airport, fly to Key West International Airport

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Key West International Airport (EYW)plane plane ILM - EYW
    11h 2m
    $211–517

Myrtle Beach (MYR) to Key West International Airport (EYW) flights

Calendar42Weekly Planes
Duration5h 50mAverage Duration
Ticket$65Cheapest Price
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Comparing Your Travel Options

Map of how to get from North Myrtle Beach to Florida Keys.ExpandLaunch map view
  • Distance: 693 mi
  • Duration: 8h 19m

What companies run services between North Myrtle Beach, SC, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Myrtle Beach (MYR) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from North Myrtle Beach to Florida Keys via Myrtle Beach Bus Station, Wilmington Cape Fear Public Transit, Fayetteville Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 28h.

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