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How to get fromNorthbrook to Mayo Clinicby train, bus, plane, car, subway, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Northbrook to Mayo Clinic by train, bus, plane, car, subway, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the train from Northbrook to Edgebrooktrain train
    2. Take the bus from Lehigh & Devon to Jefferson Park Transit Centerbus bus
    3. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 45m
    $48–322

  2. Train, bus

    1. Take the train from Glenview Amtrak Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    9h 3m
    $90–144

  3. Train, bus via Saint Paul

    1. Take the train from Glenview Amtrak Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    10h 48m
    $131–274

  4. Drive  322.3 mi

    1. Drive from Northbrook to Mayo Cliniccar car 322.3 mi
    5h 44m
    $59–85

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 22m
    $319–764

  6. Train, subway to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Northbrook to Chicago Union Stationtrain train
    2. Take the subway from LaSalle/Van Buren to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    4. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 15m
    $133–552

  7. Bus

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    10h 46m
    $80–134

  8. Bus via Chicago

    1. Take the bus from Chicago Bus Station to Madisonbus bus FlixBus 2548 / ...
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    11h 14m
    $79–125

Northbrook to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration9h 3mAverage Duration
Ticket$90Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Northbrook to Mayo Clinic.ExpandLaunch map view
  • Distance: 297.6 mi
  • Duration: 4h 45m

What companies run services between Northbrook, Cook County, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from Shermer Walters to Mayo Clinic via Old Orchard Mall - Macys, Skokie Yellow Line Station, Dempster - Skokie CTA Station, Multi-Modal/Rental Car Facility, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 10h 46m.

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