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How to get fromO'Hare to Des Moinesby plane, train, bus, car, subway, or bus (Greyhound)

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There are 6 ways to get from O'Hare to Des Moines by plane, train, bus, car, subway, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago O'Hare International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    2h 47m
    $60–288

  2. Drive  326.3 mi

    cheapest
    1. Drive from O'Hare to Des Moinescar car 326.3 mi
    5h 29m
    $56–81

  3. Train, bus

    1. Take the train from La Grange Amtrak to Galesburg Amtrak Stationtrain train Carl Sandburg / ...
    2. Take the bus from Galesburg to Des Moinesbus bus Greyhound US0157S
    9h 57m
    $117–193

  4. Subway, subway to Chicago Midway International Airport, fly

    1. Take the subway from Cumberland to Clark/Lakesubway subway
    2. Take the subway from Clark/Lake to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    3h 47m
    $88–463

  5. Bus (Greyhound)

    1. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S / ...
    10h 5m
    $68–104

  6. Train, bus via Clark/Lake

    1. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train Southwest Chief / ...
    2. Take the bus from Galesburg to Des Moinesbus bus Greyhound US0157S
    10h 21m
    $122–205

O'Hare to Des Moines by bus and train

Calendar14Weekly Services
Duration9h 57mAverage Duration
Ticket$117Cheapest Price
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Comparing Your Travel Options

Map of how to get from O'Hare to Des Moines.ExpandLaunch map view
  • Distance: 307.8 mi
  • Duration: 2h 47m

What companies run services between O'Hare, IL, USA and Des Moines, IA, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM) every 2 hours. Alternatively, Greyhound USA operates a bus from Chicago Bus Station to Des Moines 5 times a day. Tickets cost $65–100 and the journey takes 8h 25m.

Airlines
Train operators
Bus operators

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