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How to get fromO'Hare to Louisvilleby plane, bus (Greyhound, Amtrak), train, bus, car, subway, or bus (Amtrak)

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There are 7 ways to get from O'Hare to Louisville by plane, bus (Greyhound, Amtrak), train, bus, car, subway, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Louisville International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    3h 49m
    $74–478

  2. Bus (Amtrak)

    cheapest
    1. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    9h 27m
    $52–62

  3. Bus via Indianapolis

    1. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    8h 34m
    $58–103

  4. Train, bus (Amtrak)

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    9h 38m
    $128–223

  5. Drive  307.7 mi

    1. Drive from O'Hare to Louisvillecar car 307.7 mi
    5h 24m
    $57–82

  6. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    3h 51m
    $56–294

  7. Subway, subway to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the subway from Cumberland to Clark/Lakesubway subway
    2. Take the subway from Clark/Lake to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    4h 37m
    $106–713

O'Hare to Louisville by subway and bus

Calendar14Weekly Services
Duration8h 34mAverage Duration
Ticket$58Cheapest Price
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Comparing Your Travel Options

Map of how to get from O'Hare to Louisville.ExpandLaunch map view
  • Distance: 295.6 mi
  • Duration: 3h 49m

What companies run services between O'Hare, IL, USA and Louisville, KY, USA?

American Airlines and United Airlines fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a subway from Cumberland to Louisville, KY via Kedzie-Homan, Harrison & Kedzie, Jefferson & Harrison, Chicago Bus Station, and Indianapolis Union Station in around 8h 34m.

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Need to know: Greyhound

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