There are 7 ways to get from O'Hare to St. Louis by plane, train (Amtrak), bus (Flixbus), car, subway, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago O'Hare International Airport
best- Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane ORD - STL
3h 11m$326–708Bus (Flixbus)
cheapest- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus 2510 / ...
7h 45m$47–78Train (Amtrak)
- Take the train from Chicago Union Station to St. Louistrain Lincoln Service / ...
6h 35m$76–178Drive 296.6 mi
- Drive from O'Hare to St. Louiscar 296.6 mi
4h 59m$55–79Subway, subway to Chicago Midway International Airport, fly
- Take the subway from Cumberland to Clark/Lakesubway
- Take the subway from Clark/Lake to Midwaysubway
- Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane MDW - STL
4h 8m$82–563Bus to General Mitchell International Airport, fly
- Take the bus from Multi-Modal/Rental Car Facility to Mitchell Airportbus
- Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane MKE - STL
5h 14m$520–893Bus, train
- Take the bus from Multi-Modal Facility to Uptown Stationbus Peoria line
- Take the train from Bloomington-Normal to St. Louistrain Lincoln Service / ...
8h 17m$82–152
O'Hare to St. Louis by subway, foot, bus, and train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from O'Hare to St. Louis is to bus which costs $45 - $80 and takes 7h 45m.
The fastest way to get from O'Hare to St. Louis is to fly which takes 3h 11m and costs $320 - $750.
No, there is no direct bus from O'Hare to St. Louis station. However, there are services departing from Chicago and arriving at St Louis Bus Station via Chicago Bus Station. The journey, including transfers, takes approximately 7h 45m.
No, there is no direct train from O'Hare to St. Louis. However, there are services departing from Cumberland and arriving at St. Louis via Chicago Union Station. The journey, including transfers, takes approximately 6h 35m.
The distance between O'Hare and St. Louis is 278 miles. The road distance is 298.3 miles.
The best way to get from O'Hare to St. Louis without a car is to train which takes 6h 35m and costs $75 - $180.
It takes approximately 3h 11m to get from O'Hare to St. Louis, including transfers.
O'Hare to St. Louis bus services, operated by Flixbus USA, depart from Chicago Bus Station.
O'Hare to St. Louis train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from O'Hare to St. Louis is to fly which takes 3h 11m and costs $320 - $750. Alternatively, you can train, which costs $75 - $180 and takes 6h 35m, you could also bus, which costs $45 - $80 and takes 7h 45m.
What companies run services between O'Hare, IL, USA and St. Louis, MO, USA?
American Airlines, GoJet Airlines, and United Airlines fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $70–170 and the journey takes 4h 46m.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- $75–550
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 18m
- When
- Every day
- Estimated price
- $90–600
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago Midway International Airport
- Ave. Duration
- 3h 2m
- When
- Every day
- Estimated price
- $90–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $70–170
- Website
- Amtrak
Train from Bloomington-Normal to St. Louis
- Ave. Duration
- 2h 45m
- Frequency
- 5 times a day
- Estimated price
- $35–90
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 55m
- Frequency
- Twice daily
- Estimated price
- $45–75
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
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Booking & Getting There
O'Hare to St. Louis bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
O'Hare to St. Louis train services, operated by Amtrak, arrive at St. Louis station.
Yes, the driving distance between O'Hare to St. Louis is 298 miles. It takes approximately 4h 59m to drive from O'Hare to St. Louis.
Book your O'Hare to St. Louis bus tickets online with Omio and FlixBus.
There are 559+ hotels available in St. Louis.