Rome2Rio

How to get fromOFallon to Knoxvilleby plane, bus (Greyhound), train, bus, or car

Find Transport to Knoxville

See all options

There are 6 ways to get from OFallon to Knoxville by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    4h 40m
    $236–930

  2. Drive 513.4 mi

    cheapest
    1. Drive from OFallon to Knoxvillecar car 513.4 mi
    8h 34m
    $94–136

  3. Bus

    1. Take the bus from St Louis Bus Station to Newark Penn Stationbus bus Greyhound US0421
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 14m
    $333–525

  4. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    42h 12m
    $591–1,083

  5. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Chattanooga Metropolitan Airport (CHA)plane plane STL - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 50m
    $229–988

  6. Bus via Farragut

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    40h 58m
    $390–628

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$135Cheapest Price
See schedules

Questions & Answers

Map of how to get from OFallon to Knoxville.ExpandLaunch map view
  • Distance: 437.5 mi
  • Duration: 4h 40m

What companies run services between OFallon, MO, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a vehicle from OFallon to Knoxville via Riverport @ Amphitheater Nb, North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St Louis Bus Station, Newark, Penn Station, Newark Penn Station, Penn Station, 34 St-Herald Sq, East Broadway, New York, NY, and Knoxville, TN in around 40h 14m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers