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How to get fromOFallon to Knoxvilleby plane, bus (Greyhound), train, bus, or car

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There are 6 ways to get from OFallon to Knoxville by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    3h 46m
    $246–980

  2. Drive  513.4 mi

    cheapest
    1. Drive from OFallon to Knoxvillecar car 513.4 mi
    8h 34m
    $94–136

  3. Bus

    1. Take the bus from St Louis Bus Station to Newark Penn Stationbus bus Greyhound US0421
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 17m
    $333–475

  4. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    42h 13m
    $511–963

  5. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Chattanooga Metropolitan Airport (CHA)plane plane STL - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 28m
    $144–528

  6. Bus via Farragut

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    40h 53m
    $390–568

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar123Weekly Planes
Duration4h 14mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from OFallon to Knoxville.ExpandLaunch map view
  • Distance: 437.5 mi
  • Duration: 3h 46m

What companies run services between OFallon, MO, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a vehicle from OFallon to Knoxville via Riverport @ Amphitheater Nb, North Hanley Transit Center, NORTH HANLEY station, CIVIC CENTER station, St Louis Bus Station, Newark, Penn Station, Newark Penn Station, Penn Station, 34 St-Herald Sq, East Broadway, New York, NY, and Knoxville, TN in around 40h 17m.

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