There are 7 ways to get from Ocala to Des Moines by taxi, plane, bus, train, car, shuttle, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Gainesville Regional Airport, fly
best- Take the taxi from Ocala to Gainesville-Airport-GNVtaxi
- Fly from Gainesville Regional Airport (GNV) to Des Moines (DSM)plane GNV - DSM
5h 32m$257–659Drive to Orlando Sanford, fly
cheapest- Drive from Ocala to Orlando-Sanford-Airport-SFBcar
- Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane SFB - DSM
4h 47m$127–523Bus, train via Atlanta
- Take the bus from Ocala Bus Stop to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to St Louis Bus Stationbus
- Take the train from St. Louis to Kansas Citytrain
- Take the bus from Kansas City Bus Station to Des Moinesbus
30h 28m$330–532Bus, train
- Take the bus from Ocala Amtrak Bus Stop to Jacksonvillebus
- Take the train from Jacksonville to Chicago Union Stationtrain
- Take the bus from Chicago Bus Station to Des Moinesbus
46h 31mDrive 1,245.1 mi
- Drive from Ocala to Des Moinescar 1,245.1 mi
21h 40m$228–329Shuttle to Orlando, fly
- Take a shuttle bus from Hiton Garden Inn Downtown Ocala to Orlando Airport
- Fly from Orlando (MCO) to Des Moines (DSM)plane MCO - DSM
7h 44m$178–543Bus
- Take the bus from Ocala Bus Stop to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus
- Take the bus from Indianapolis Union Station to Des Moinesbus
31h 10m$235–367
Ocala to Des Moines by bus, train, and foot
Comparing Your Travel Options
The cheapest way to get from Ocala to Des Moines is to drive which costs $220 - $330 and takes 21h 40m.
The fastest way to get from Ocala to Des Moines is to drive and fly which takes 4h 47m and costs $120 - $550.
No, there is no direct bus from Ocala to Des Moines. However, there are services departing from Ocala Bus Stop and arriving at Des Moines via Atlanta Bus Station and Indianapolis Union Station. The journey, including transfers, takes approximately 31h 10m.
The distance between Ocala and Des Moines is 1091 miles. The road distance is 1252.4 miles.
The best way to get from Ocala to Des Moines without a car is to bus and train via Atlanta which takes 30h 28m and costs $330 - $550.
It takes approximately 5h 32m to get from Ocala to Des Moines, including transfers.
Ocala to Des Moines bus services, operated by Flixbus USA, depart from Ocala Bus Stop station.
Ocala to Des Moines bus services, operated by Flixbus USA, arrive at Atlanta Bus Station.
Des Moines is 1h behind Ocala. It is currently 9:28 AM in Ocala and 8:28 AM in Des Moines.
Yes, the driving distance between Ocala to Des Moines is 1252 miles. It takes approximately 21h 40m to drive from Ocala to Des Moines.
What companies run services between Ocala, FL, USA and Des Moines, IA, USA?
You can take a bus from Ocala Bus Stop to Des Moines via Atlanta Bus Station and Indianapolis Union Station in around 31h 10m.
- Website
- delta.com
Flights from Gainesville Regional Airport to Des Moines via Atlanta
- Ave. Duration
- 5h 9m
- When
- Every day
- Estimated price
- $90–460
Flights from Orlando to Des Moines via Atlanta
- Ave. Duration
- 5h
- When
- Every day
- Estimated price
- $90–450
- Website
- aa.com
Flights from Gainesville Regional Airport to Des Moines via Charlotte
- Ave. Duration
- 5h 23m
- When
- Thursday to Saturday
- Estimated price
- $100–490
Flights from Gainesville Regional Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 7h 46m
- When
- Every day
- Estimated price
- $120–550
Flights from Orlando to Des Moines via Charlotte
- Ave. Duration
- 5h 31m
- When
- Thursday to Saturday
- Estimated price
- $100–480
- Website
- allegiantair.com
Flights from Orlando Sanford to Des Moines
- Ave. Duration
- 2h 54m
- When
- Friday, Monday, Wednesday, and Saturday
- Estimated price
- $95–480
- Website
- southwest.com
Flights from Orlando to Des Moines via Chicago Midway
- Ave. Duration
- 5h 15m
- When
- Saturday to Wednesday
- Estimated price
- $100–480
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from St. Louis to Kansas City
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $150–240
- Website
- Amtrak
Train from Jacksonville to Chicago Union Station
- Ave. Duration
- 35h 12m
- Frequency
- Once daily
- Estimated price
- $850–1,400
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Ocala Bus Stop to Atlanta Bus Station
- Ave. Duration
- 7h 30m
- Frequency
- 3 times a day
- Estimated price
- $55–90
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 10h 21m
- Frequency
- 5 times a week
- Estimated price
- $85–130
- Schedules at
- Flixbus USA
Bus from Ocala Bus Stop to Atlanta Bus Station
- Ave. Duration
- 7h 30m
- Frequency
- 3 times a day
- Estimated price
- $55–90
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Once daily
- Estimated price
- $95–150
- Website
- Greyhound
Bus from Kansas City Bus Station to Des Moines
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- Greyhound
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 30m
- Frequency
- 3 times a day
- Estimated price
- $60–90
- Website
- Greyhound
Bus from Atlanta Bus Station to Indianapolis Union Station
- Ave. Duration
- 11h 50m
- Frequency
- 4 times a day
- Estimated price
- $95–150
- Website
- Greyhound
Bus from Indianapolis Union Station to Des Moines
- Ave. Duration
- 9h 50m
- Frequency
- Once daily
- Estimated price
- $80–130
- Website
- Greyhound
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Ocala Amtrak Bus Stop to Jacksonville
- Ave. Duration
- 2h 40m
- Frequency
- Once daily
- Website
- Amtrak
- Phone
- +1 352-237-9900
Shuttle from Hiton Garden Inn Downtown Ocala to Orlando Airport
- Ave. Duration
- 2h
- Frequency
- On demand
- Estimated price
- $70
- Schedules at
- Shuttleliner of Ocala
- Ave. Duration
- 50 min
- Estimated price
- $140–180
Signature Taxi
- Phone
- +1 352-207-2008
- Website
- signatureshuttle.net
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Booking & Getting There
There are 237+ hotels available in Des Moines.








