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How to get fromOhio to Des Moinesby plane, bus (Flixbus, Greyhound), car, bus, bus (Greyhound), or train

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There are 10 ways to get from Ohio to Des Moines by plane, bus (Flixbus, Greyhound), car, bus, bus (Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Cleveland-Hopkins International Airport

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM)plane plane CLE - DSM
    5h 18m
    $160–824

  2. Bus via Indianapolis (Greyhound)

    cheapest
    1. Take the bus from Columbus to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    15h 5m
    $92–181

  3. Bus

    1. Take the bus from Columbus to Chicago Bus Stationbus bus FlixBus 2511 / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    15h
    $99–182

  4. Drive 620.1 mi

    1. Drive from Columbus to Des Moinescar car 620.1 mi
    11h 27m
    $114–164

  5. Fly from John Glenn Columbus International Airport

    1. Fly from John Glenn Columbus International Airport (CMH) to Des Moines (DSM)plane plane CMH - DSM
    5h 28m
    $159–874

  6. Fly from Covington

    1. Fly from Covington (CVG) to Des Moines (DSM)plane plane CVG - DSM
    5h 48m
    $161–875

  7. Fly from Dayton

    1. Fly from Dayton (DAY) to Des Moines (DSM)plane plane DAY - DSM
    5h 52m
    $159–873

  8. Fly from Akron

    1. Fly from Akron (CAK) to Des Moines (DSM)plane plane CAK - DSM
    5h 47m
    $141–688

  9. Bus to Detroit, fly

    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Des Moines (DSM)plane plane DTW - DSM
    5h 21m
    $179–816

  10. Bus, train

    1. Take the bus from Columbus - Mound St to Toledobus bus
    2. Take the train from Toledo to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    17h 59m
    $165–359

Ohio to Des Moines by bus

Calendar15Weekly Buses
Duration15hAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Ohio to Des Moines.ExpandLaunch map view
  • Distance: 629 mi
  • Duration: 5h 18m

What companies run services between Ohio, USA and Des Moines, IA, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Columbus to Des Moines via Chicago Bus Station in around 15h.

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Train operators
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